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FLASH GENE
Symbol FRMD6 contributors: mct - updated : 21-05-2012
HGNC name FERM domain containing 6
HGNC id 19839
Location 14q22.1      Physical location : 51.955.854 - 52.197.442
Synonym name chromosome 14 open reading frame 31
Synonym symbol(s) MGC17921, c14_5329, C14orf31, willin
DNA
TYPE functioning gene
STRUCTURE 241.59 kb     14 Exon(s)
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 5050 - 614 - 2006 16341207
14 - 4842 - 614 - 2006 16341207
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemuterus   
 female systemplacenta   
Skin/Tegumentskin appendageshairfollicle  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a 4.1 Ezrin Radixin Moesin (FERM) domain
HOMOLOGY
interspecies ortholog to Chimpanzee C14orf31
ortholog to murine Frmd6
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,cytoskeleton
text can be cytoplasmic or at the plasma membrane where it can co-localize with actin
basic FUNCTION
  • having a recognizable FERM domain within its N-terminus and capable of binding phospholipids
  • in mammalian cells, influences Hippo signaling activity by activating the core Hippo pathway kinase cassette
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • FRMD6/PARD3-PRKCI-ROCK1 pathway that controls epithelial apical morphology
  • INTERACTION
    DNA
    RNA
    small molecule other,
    binding phospholipids
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS