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FLASH GENE
Symbol FRAT2 contributors: mct/ - updated : 18-11-2014
HGNC name frequently rearranged in advanced T-cell lymphomas 2
HGNC id 16048
Location 10q24.1      Physical location : 99.092.253 - 99.094.458
Synonym name GSK-3 binding protein FRAT2
Synonym symbol(s) FRT2, MGC10562
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation, tail to tail
text in opposite orientation with FRAT1
STRUCTURE 2.21 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 2222 - 233 - 2001 11237732
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart    
Digestiveliver   highly
Endocrinepancreas   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines gastric and cervical cancers and chronic myelogenous leukemia cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, kidney, highly
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • a N terminal acidic domain
  • a proline-rich domain and a GSK3B-binding near the C terminus
  • HOMOLOGY
    interspecies homolog to C.elegans FO8B4.4
    intraspecies homolog to FRAT1
    Homologene
    FAMILY
  • GSK3 binding protein family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • implicated in tumor progression through activation of WNT signaling pathway
  • preventing GSK3 dependent phosphorylation
  • inhibiting the phosphorylation of beta catenin
  • preventing beta catenin degradation by the ubiquitin-proteasome pathway
  • with FRAT1 may also function to bridge canonical and noncanonical Wnt pathways
  • mediates the oncogenic activation of RAC1 by KMT2A fusions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GSK3
  • significantly increased GSK3B-mediated phosphorylation of MAPT at a primed epitope while not significantly affecting the phosphorylation of unprimed sites
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS