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FLASH GENE

Symbol

FRAT1

contributors: mct - updated : 02-02-2011

HGNC name	frequently rearranged in advanced T-cell lymphomas
HGNC id	3944

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q24.1      Physical location : 99.079.021 - 99.081.672
Synonym name	proto-oncogene FRAT1
	GSK3 beta binding protein FRAT1
Synonym symbol(s)	FLJ97193

DNA

TYPE	functioning gene
SPECIAL FEATURE	opposite orientation, tail to tail
text	in opposite orientation with FRAT2
STRUCTURE	2.65 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005479 1 - 2651 28.9 279 - 2006 16982607

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Digestive salivary gland       highly Endocrine neuroendocrine pituitary     highly Reproductive male system prostate     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	a N-terminal acidic domain
	a proline-rich-domain
	a GSK3B-binding domain near the C-terminus

HOMOLOGY

interspecies	homolog to murine Frat1,Frat3
	homolog to C.elegans F42a10.5

intraspecies

homolog to FRAT2

Homologene

FAMILY

GSK3-binding protein family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	playing a role in tumor progression
	collaborating with PIM1 and MYC in lymphomagenesis
	preventing GSK3-dependent phosphorylation
	positive regulator fo the WNT signaling pathway, preventing beta-catenin degradation by the ubiquitin-proteasome pathway and promotor of cacinogenesis
	inhibit glycogen synthase kinase-3-mediated phosphorylation of beta-catenin
	proto-oncogene involved in tumorigenesis
	may be an important factor in the tumorigenesis and progression of gliomas
	with FRAT2 may also function to bridge canonical and noncanonical Wnt pathways
	may be an important factor in the tumorigenesis and progression of astrocytoma

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

inhibiting the phosphorylation of beta catenin

INTERACTION

DNA

RNA

small molecule

protein

GSK3

cell & other

REGULATION

Other

phosphorylated by PKA (may play a role in regulating the inhibitory activity of FRAT1 toward GSK-3)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   lymphomas, gastric and pancreatic cancer constitutional     --over   induced the nuclear accumulation of beta-catenin and promoted the transcriptional activity of beta-catenin/T-cell factor tumoral     --over   significantly promoted esophageal cancer cells (ESCC) growth and MYC may be an important element in oncogenesis of human ESCC induced by FRAT1

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain   could be used as a potential molecular marker for pathological diagnosis and a target for biological therapy in gliomas cancer     potential biomarker for pathological diagnosis of malignancy and a target for biological therapy

ANIMAL & CELL MODELS