basic FUNCTION
| playing a role in tumor progression |
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collaborating with PIM1 and MYC in lymphomagenesis |
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preventing GSK3-dependent phosphorylation |
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positive regulator fo the WNT signaling pathway, preventing beta-catenin degradation by the ubiquitin-proteasome pathway and promotor of cacinogenesis |
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inhibit glycogen synthase kinase-3-mediated phosphorylation of beta-catenin |
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proto-oncogene involved in tumorigenesis  |
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may be an important factor in the tumorigenesis and progression of gliomas  |
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with FRAT2 may also function to bridge canonical and noncanonical Wnt pathways  |
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may be an important factor in the tumorigenesis and progression of astrocytoma  |