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FLASH GENE
Symbol FRAT1 contributors: mct - updated : 02-02-2011
HGNC name frequently rearranged in advanced T-cell lymphomas
HGNC id 3944
Location 10q24.1      Physical location : 99.079.021 - 99.081.672
Synonym name
  • proto-oncogene FRAT1
  • GSK3 beta binding protein FRAT1
    • Synonym symbol(s) FLJ97193
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation, tail to tail
    text in opposite orientation with FRAT2
    STRUCTURE 2.65 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DNTT 10q24 deoxynucleotidyltransferase, terminal TMEM10 10q23-q24 transmembrane protein 10 TLL2 10q23-q24 tolloid-like 2 SMBP 10q24.2 SM-11044 binding protein PIK3AP1 10q24.2 phosphoinositide-3-kinase adaptor protein 1 LOC283340 10q24.2 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC387709 10 LOC387709 C10orf12 10q24.2 chromosome 10 open reading frame 12 SLIT1 10q23.3-q24 slit homolog 1 (Drosophila) ARHGAP19 10q24.2 Rho GTPase activating protein 19 FRAT1 10q24.1 frequently rearranged in advanced T-cell lymphomas FRAT2 10q23-q24.1 frequently rearranged in advanced T-cell lymphomas 2 KIAA0690 10q23.33 frequently rearranged in advanced T-cell lymphomas 2 PGAM1 10q25.3 phosphoglycerate mutase 1 (brain) CSL4 10q24 exosomal core protein CSL4 ZDHHC16 10q24.1 zinc finger, DHHC domain containing 16 MMS19L 10q24-q25 MMS19-like (MET18 homolog, S. cerevisiae) FLJ11807 10q24.2 hypothetical protein FLJ11807 ANKRD2 10q23.31-q23.32 ankyrin repeat domain 2 (stretch responsive muscle) LOC112817 10q24.2 hypothetical protein BC011916 LOC118812 10q24.2 44050 protein PI4KII 10q24 44050 protein VIP32 10q24.2 vasopressin-induced transcript MGC4415 10q24.2 hypothetical protein MGC4415 FLJ32919 10q24.2 hypothetical protein FLJ32919 SFRP5 10q24.1 secreted frizzled-related protein 5 CRTAC1 10q22 cartilage acidic protein 1 C10orf28 10q24.2 chromosome 10 open reading frame 28 LOXL4 10q24 lysyl oxidase-like 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2651 28.9 279 - 2006 16982607
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Digestivesalivary gland   highly
    Endocrineneuroendocrinepituitary  highly
    Reproductivemale systemprostate  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • a N-terminal acidic domain
  • a proline-rich-domain
  • a GSK3B-binding domain near the C-terminus
    • HOMOLOGY
    interspecies homolog to murine Frat1,Frat3
    homolog to C.elegans F42a10.5
    intraspecies homolog to FRAT2
    Homologene
    FAMILY
  • GSK3-binding protein family
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • playing a role in tumor progression
  • collaborating with PIM1 and MYC in lymphomagenesis
  • preventing GSK3-dependent phosphorylation
  • positive regulator fo the WNT signaling pathway, preventing beta-catenin degradation by the ubiquitin-proteasome pathway and promotor of cacinogenesis
  • inhibit glycogen synthase kinase-3-mediated phosphorylation of beta-catenin
  • proto-oncogene involved in tumorigenesis
  • may be an important factor in the tumorigenesis and progression of gliomas
  • with FRAT2 may also function to bridge canonical and noncanonical Wnt pathways
  • may be an important factor in the tumorigenesis and progression of astrocytoma
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • inhibiting the phosphorylation of beta catenin
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GSK3
    • cell & other
    REGULATION
    Other phosphorylated by PKA (may play a role in regulating the inhibitory activity of FRAT1 toward GSK-3)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    lymphomas, gastric and pancreatic cancer
    constitutional     --over  
    induced the nuclear accumulation of beta-catenin and promoted the transcriptional activity of beta-catenin/T-cell factor
    tumoral     --over  
    significantly promoted esophageal cancer cells (ESCC) growth and MYC may be an important element in oncogenesis of human ESCC induced by FRAT1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    could be used as a potential molecular marker for pathological diagnosis and a target for biological therapy in gliomas
    cancer  
    potential biomarker for pathological diagnosis of malignancy and a target for biological therapy
    ANIMAL & CELL MODELS