| SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic,vesicle
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| text
| extracellular matrix protein, basement membrane-associated protein |
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prominently expressed in vesicles, which are epithelial spheroids arising from metanephric mesenchyme (MM) aggregates  |
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FRAS1 and FREM2 were colocalized with FREM3 in the basement membrane of certain skin parts, underlying the thin-layer, of rapidly proliferating keratinocytes, whereas FREM1 was detected only in the basement membrane of the tail |
| basic FUNCTION
| involved in electron transport and probably in metanephronic differentiation |
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having a role in both structure and signal propagation during embryonic development |
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may be required for the formation of normal glomeruli |
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needed for the initiation of the metanephric kidney but also may have a function at a later stage of development, namely in the formation of glomeruli, filtering units of the kidney |
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not only initiates kidney development but may also be required for the formation of normal glomeruli |
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involved in the structural adhesion of the skin epithelium to its underlying mesenchyme |
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not only essential as a component of a macromolecular complex for the extracellular stabilization of FREM2 but it is also required for its proper intracellular trafficking and export from embryonic epithelial cells |
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share common polypeptide repetitive motifs with possible interactive and organizing functions |
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potentially compensate for the activity of collagen VII, a major anchoring component of the sublamina densa, the levels of which rise only during late embryonic life |
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having a role in the structure and function of basement membrane |
