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FLASH GENE
Symbol FPR3 contributors: mct - updated : 01-04-2014
HGNC name formyl peptide receptor 3
HGNC id 3828
Location 19q13.41      Physical location : 52.298.410 - 52.329.334
Synonym name
  • formyl peptide receptor-like 2
  • FMLP-related receptor II
  • Synonym symbol(s) FPRH1, FMLPY, FPRH2, RMLP-R-I, FPRL2, FPRH2, FMLP-R-II
    DNA
    TYPE functioning gene
    STRUCTURE 30.92 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text transcriptional variations of FPR3 occur by an alternative promoter during primate evolution (PMID: 21717223)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2517 - 353 - 2011 2171722
    FPR3-1
    - - - - - tissue-specific patterns with strong expressions in lung or uterus 2011 21717223
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Nervousbrain   lowly
    Reproductivefemale systemuterus  highly Homo sapiens
    Respiratorylung   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Blood/Hematopoieticneutrophil
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane domains (7TM) receptor
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to C.elegans T27D1.3
    intraspecies homolog to FPR1
    homolog to FPR2 (83 p100)
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • FPR2 was evenly distributed at the plasma membrane, but FPR3 was localized in small intracellular vesicles, and a clathrin-independent, possibly caveolae-dependent, mechanism was involved in FPR3 constitutive internalization
  • basic FUNCTION
  • acting as a rhodopsin-like receptor
  • acting as a low affinity receptor to N-formyl-methionyl peptides
  • potential player in innate immunity and appears with FPR2 as a FPR cluster during primate evolution
  • FPR1, FPR2, FPR3, are critical for normal healing of the sterile skin wound by mediating the first wave of neutrophil infiltration
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS immunity/defense
    text chemotaxis
    PATHWAY
    metabolism
    signaling signal transduction
    a component FPR2 might exist as homo- or heterodimer with FPR1 or FPR3 (the two other family members) and operate in a ligand-biased fashion
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by HEBP1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS