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FLASH GENE
Symbol FPR1 contributors: mct - updated : 01-04-2014
HGNC name formyl peptide receptor 1
HGNC id 3826
Location 19q13.41      Physical location : 52.249.022 - 52.255.150
Synonym name
  • formyl peptide (N-formyl-Met-Leu-Phe-Lys) (bacterial) receptor 1
  • N-formylpeptide chemoattractant receptor
  • fMLP receptor
  • fMet-Leu-Phe receptor
  • Synonym symbol(s) FMLP, FPR
    DNA
    TYPE functioning gene
    STRUCTURE 6.12 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • a consensus binding site for the transcription factor SPI1
  • FPR1 promoter activity requires SPI1
  • MAPPING cloned Y linked N status confirmed
    Physical map
    FLJ40235 19q13.41 hypothetical protein FLJ40235 LOC339351 19q13.41 similar to hypothetical protein LOC162952 19q13.41 similar to Opioid binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML) LOC147645 19q13.41 hypothetical protein LOC147645 ETFB 19q13.4 electron-transfer-flavoprotein, beta polypeptide MGC33839 19q13.41 hypothetical protein MGC33839 NKG7 19q13.4 natural killer cell group 7 sequence LIM2 19q13.4 lens intrinsic membrane protein 2, 19kDa LOC147646 19q13.41 hypothetical protein LOC147646 LOC388557 19 similar to nucleolar phosphoprotein Nopp34 SIGLEC10 19q13.3 sialic acid binding Ig-like lectin 10 SIGLEC8 19q13.33-q13.41 sialic acid binding Ig-like lectin 8 SIGLECL1 19q13.4 SIGLEC-like 1 SIGLEC6 19q13.3 sialic acid binding Ig-like lectin 6 ZNF175 19q13.4 zinc finger protein 175 LOC147649 19q13.41 hypothetical LOC147649 LOC339352 19q13.41 hypothetical LOC339352 SIGLEC5 19q13.4 sialic acid binding Ig-like lectin 5 LOC147650 19q13.41 hypothetical protein LOC147650 HAS1 19q13.3-q13.4 hyaluronan synthase 1 FPR1 19q13.4 formyl peptide receptor 1 FPRL1 19q13.4 formyl peptide receptor-like 1 FPRL2 19q13.3-q13.4 formyl peptide receptor-like 2 LOC390957 19 similar to Zinc finger protein 84 (Zinc finger protein HPF2) MGC4400 19q13.41 hypothetical protein MGC4400 FLJ12644 19q13.41 hypothetical protein FLJ12644 LOC390958 19 similar to ZNF84 protein FLJ13590 19q13.41 hypothetical protein FLJ13590 ZNF350 19q13.4 zinc finger protein 350 FLJ33710 19q13.41 FLJ33710 protein FLJ21941 19q13.41 FLJ21941 protein ZNF432 19q13.41 zinc finger protein 432 LOC284371 19q13.41 hypothetical protein LOC284371 MGC45556 19q13.41 hypothetical protein MGC45556 LOC90317 19q13.41 hypothetical protein LOC90317 LOC147655 19q13.41 similar to ribosomal protein L37 LOC162962 19q13.41 similar to Zinc finger protein Kr18 (HKr18)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1334 - 350 - 1992 1373134
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Reproductivefemale systemovary   
     female systemuterus   
    Respiratorylung    
    Visualeyelens    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte Homo sapiens
    Blood/Hematopoieticmonocyte Homo sapiens
    Blood/Hematopoieticneutrophil Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    Visualepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • C-terminal phosphorylation sites
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • secretin receptor superfamily
  • G-protein coupled receptor 1 family
  • formyl peptide receptor (FPR) family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • mediating chemotaxis and inducing leukocyte activation
  • receptor for n-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors
  • novel role for FPR1 stimulation in enhancing intestinal epithelial cell restitution through PI3K-dependent activation of RAC1 and CDC42
  • expression of FPR1 in myeloid cells is developmentally regulated
  • lens epithelial cell FPR1 may be involved in development and maintenance of the lens
  • role for FPR1 to chemotaxis and superoxide production of resting and pro-inflammatory M1 macrophages
  • fundamental difference between the two neutrophil FPR1 and FPR2, regarding their sensitivities to third intracellular loop pepducins
  • FPR1, FPR2, FPR3, are critical for normal healing of the sterile skin wound by mediating the first wave of neutrophil infiltration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • FPR2 might exist as homo- or heterodimer with FPR1 or FPR3 (the two other family members) and operate in a ligand-biased fashion
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coupling with Gs alpha protein and activating adenylate cyclase, leukocyte membrane glycoprotein
  • possible signaling role for ANXA1 in mitogen-activated proliferation of breast tumor epithelial cells that is mediated via activation of FPR1 and FPR2
  • different structural determinants are used by FPR1 and FPR2 to interact with formyl peptides
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS