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FLASH GENE
Symbol FOXRED1 contributors: mct - updated : 23-03-2011
HGNC name FAD-dependent oxidoreductase domain containing 1
HGNC id 26927
Corresponding disease
MEIO mitochondrial encephalopathy, infantile-onset.
Location 11q24.2      Physical location : 126.139.054 - 126.148.026
Synonym symbol(s) H17, FP634
DNA
TYPE functioning gene
STRUCTURE 8.97 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1967 53 486 - 2010 20858599
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal mitochondrial targeting sequence which was masked by the N-terminal fusion process
  • FAD-dependent oxidoreductase domain, which may be involved in electron transfer
    • HOMOLOGY
    interspecies homolog to murine Foxred1 (79.4pc)
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • FAD-dependent oxidoreductase complex-I-specific molecular chaperone
  • may enter the mitochondrial matrix as a precursor containing its mitochondrial import sequence, which is then cleaved to release the mature functional protein
  • must be a chaperone or other factor necessary for assembly, stability and/or correct functioning of complex I
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MEIO
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS