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FLASH GENE
Symbol FOXP4 contributors: - updated : 26-01-2006
HGNC name forkhead box P4
HGNC id 20842
Location 6p21.1      Physical location : 41.514.163 - 41.570.121
Synonym name
  • winged-helix repressor FOXP4
  • fork head-related protein like A
  • Synonym symbol(s) FKHLA, FLJ40908, FLJ44184
    DNA
    TYPE functioning gene
    STRUCTURE 55.96 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 5965 - 680 - Katoh (2004)
    17 - 5926 - 667 - Katoh (2004)
    17 - 5959 - 678 - Katoh (2004)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratorylung    
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text developing lung and gut
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one forkhead domain
  • N-terminal repression domain
  • one C2H2-type zinc finger
  • HOMOLOGY
    interspecies ortholog to murine Foxp4
    homolog to chimpanzee foxp4
    homolog to dog LOC481793
    Homologene
    FAMILY
  • subfamily P of the forkhead box (FOX)
  • transcription factor family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may play a role in the development of tumors of the kidney and larynx
  • transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase
  • involved in regulation of transcription, DNA-dependent
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    repressed by regulated by homo- and heterodimerization
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in kidney tumor, larynx carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS