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FLASH GENE
Symbol FOXO6 contributors: mct/npt - updated : 20-07-2009
HGNC name forkhead box protein O6
HGNC id 24814
Location 1p34.2      Physical location : -
DNA
TYPE functioning gene
STRUCTURE 20.75 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
Text most apparent in the developing brain, and is expressed in a specific temporal and spatial pattern (Jacobs 2003)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three highly conserved regions containing a PKB phosphorylation motif (Jacobs 2003)
  • HOMOLOGY
    Homologene
    FAMILY
  • forkhead transcription factors family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • probably involved in regulation of specific cellular differentiation (Jacobs 2003)
  • its nuclear export is mediated through the phosphatidylinositol 3-kinase/PKB pathway (Jacobs 2003)
  • play an important role in a variety of processes, such as cell cycle arrest, cell death, tumor suppression, metabolism, and protection from oxidative stress (Sakamaki 2009)
  • mediator of autophagy, having the ability to induce cell cycle arrest, DNA repair and apoptosis )
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS