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FLASH GENE
Symbol FOXN4 contributors: mct/ - updated : 14-10-2015
HGNC name forkhead box N4
HGNC id 21399
Location 12q24.11      Physical location : 109.715.783 - 109.747.025
Synonym name
  • forkhead/winged helix transcription factor FOXN4
  • forkhead box protein N4
  • Synonym symbol(s) FLJ35967
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    STRUCTURE 31.24 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3356 - 517 - 2004 15492871
  • isoform 2
  • exons 1-10
  • - - - - 518 - 2004 15492871
    exons 1-2-7v and 8 to 10
    - - - - 314 - 2004 15492871
    exons 1 to 5 and 7 to 10
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    Nervousbrain     Rattus norvegicus
     spinal cord     Rattus norvegicus
    Reproductivemale systemtestis   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentralgray matter   Rattus norvegicus
    Nervouscentralwhite matter   Rattus norvegicus
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte Rattus norvegicus
    Nervousneuron Rattus norvegicus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a fork-head DNA-binding domain
  • a domain between AAs 402 and 455 is necessary for FOXN4 transcriptional activity in the retina (pMID: 21701787)
  • HOMOLOGY
    intraspecies paralog to FOXN1
    Homologene
    FAMILY
  • winged-helix/forkhead family of transcription factors
  • N-family forkhead transcription factors
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional regulator involved in development
  • regulates the expression of NR4A2, a nuclear receptor that is associated with familial Parkinson's disease
  • forkhead/wing helix transcription factor with a role in the specification of cells in retinogenesis and spinal neurogenesis
  • is required for retinal ganglion cell distal axon patterning
  • may have a non-cell-autonomous role critical for alveologenesis during lung development
  • transcription factor involved in developing spinal cord and spinal neurogenesis, and implied important roles in the central nervous system (CNS)
  • might play important roles in CNS pathophysiology after spinal cord injury (SCI)
  • is a key regulator in a variety of biological processes during development
  • plays an essential role in the genesis of horizontal and amacrine neurons from neural progenitors in the vertebrate retina
  • FOXN4 exhibited substantial thymopoietic activity
  • FOXN4, RORB and their downstream effector PTF1A, have been shown to be indispensable intrinsic regulators for the differentiation of amacrine and horizontal cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • DLL4 is directly activated by FOXN4 via phylogenetically conserved enhancers and DLL4 can partly mediate the FOXN4 function by serving as a major NOTCH1 ligand to expand the progenitor pool and limit photoreceptor production
  • RORB and FOXN4 synergistically induce PTF1A expression, suggesting a central role for RORB in a transcriptional hierarchy that directs this interneuron differentiation pathway
  • MEIS1 regulates FOXN4 expression during retinal progenitor cell differentiation
  • mosaic expression of FOXN4 and proneural factors may serve as the trigger to initiate asymmetric DLL4-NOTCH1 and subsequent BMP/TGFB1 signaling events required for neuronal diversity in the V2 interneurons domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS