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Symbol FOXN1 contributors: mct - updated : 02-10-2019
HGNC name forkhead box N1
HGNC id 12765
Corresponding disease
WHN NUDE phenotype
Location 17q11.2      Physical location : 26.850.958 - 26.865.173
Synonym name
  • winged-helix nude
  • winged-helix transcription factor nude
  • Rowett nude
  • Synonym symbol(s) FKHL20, WHN, RONU
    TYPE functioning gene
    STRUCTURE 32.70 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    LOC390782 17 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) NLK 17q11.2 nemo-like kinase PYY2 17q11.1-q11.2 peptide YY, 2 (seminalplasmin) PPY2 17q11.1-q11.2 pancreatic polypeptide 2 LOC339274 17q11.2 similar to Hypothetical protein KIAA0563 FLJ40504 17q11.2 hypothetical protein FLJ40504 MAC30 17q11.2 hypothetical protein FLJ40504 LOC90410 17q11.2 intraflagellar transport protein IFT20 TNFAIP1 17q11 tumor necrosis factor, alpha-induced protein 1 (endothelial) PDIP38 MGC45714 17q11.2 hypothetical protein MGC45714 VTN 17q11.2 vitronectin (serum spreading factor, somatomedin B, complement S-protein) SARM1 17q11 sterile alpha and TIR motif containing 1 MGC9564 17q11.2 similar to RIKEN cDNA 1110002C08 gene LOC388363 17 similar to 40S ribosomal protein S7 (S8) SLC13A2 17p11.1-q11.1 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 FOXN1 17q11.2 forkhead box N1 UNC119 17q11.2 unc-119 homolog (C. elegans) PIGS 17p13.2 phosphatidylinositol glycan, class S ALDOC 17q11.2 aldolase C, fructose-bisphosphate SPAG5 17q11.1 sperm associated antigen 5 FLJ25006 17q11.2 hypothetical protein FLJ25006 KIAA0100 17q11.2 KIAA0100 gene product SDF2 17q11.2 stromal cell-derived factor 2 SUPT6H 17q11.2 suppressor of Ty 6 homolog (S. cerevisiae) MGC39650 17q11.2 hypothetical protein MGC39650 RAB34 17q11.1 RAB34, member RAS oncogene family RPL23A 17q11 ribosomal protein L23a LOC116238 17q11.2 hypothetical protein BC014072 NEK8 17q11.1 NIMA (never in mitosis gene a)- related kinase 8 TRAF4 17q11-q12 TNF receptor-associated factor 4 FLJ10700 17q11.2 hypothetical protein FLJ10700 ERAL1 17q11.2 Era G-protein-like 1 (E. coli) FLOT2 17q11.2-q12 flotillin 2 MGC23280 17q11.2 hypothetical protein MGC23280 PHF12 17q11.2 PHD finger protein 12
    regionally located tighly linked to SUPT6H
    TRANSCRIPTS type messenger
    text alternative splice in the 5'UTR
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2697 68.9 648 - 2014 25173801
    9 - 3521 - 648 - 2014 25173801
    Type restricted
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymusmedulla    Homo sapiens
    Respiratoryrespiratory tractlarynx   
    Skin/Tegumentskin     Homo sapiens
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermis   Homo sapiens
    cell lineage
    cell lines
    at STAGE
  • N-terminal domain required for crosstalk-dependent thymic epithelial cell differentiation
  • a forkhead (FH, winged-helix) domain
  • two loops-wings on the C terminal side of helix-turn-helix homeodomain
    interspecies ortholog to murine nude,winged-helix protein
  • HNF-3, FKH family of transcriptional activities
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • regulating keratin gene expression
  • may be involved in neurulation
  • implicated in a pathway that should serve as a nexus coordinating cell division, differentiation, and pigmentation
  • promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles
  • modulates stage-specific markers by modulating PKC activity, providing control over the timing of steps in the differentiation program
  • MSX2, and FOXN1, upstream of NOTCH1 within the hair matrix, play a pivotal role in inner root sheath, cortex and medulla differentiation
  • important functions for MSX2 and FOXN1 in regulating differentiation of the keratogenous zone, proliferation of distal nail matrix cells, and organization of the nail bed
  • implicated in the differentiation of thymic and skin epithelial cells
  • crucial for in utero T cell development
  • powerful regulator of thymic epithelial cell differentiation that is required at multiple intermediate stages of thymic epithelial lineage development in the fetal and adult thymus
  • is essential for thymic organogenesis and T lymphopoiesis
  • FOXN1 affects both T lymphopoiesis and hematopoiesis, and the FOXN1 bone marrow niche may function in skewing multipotent progenitors development toward T lineage progenitors
  • FOXN1 has temporal and tissue-specific activity
  • is involved in several skin functions, especially in the proliferation and the differentiation of keratinocytes which are key cells of epithelial barrier
  • acts as regulator of the skin wound healing process through engagement in re-epithelization and possible involvement in scar formation due to FOXN1 activity during the EMT process
  • FOXN1 regulates the expression of genes involved in antigen processing and thymocyte selection
  • transcription factor FOXN1 is a potential key epidermal regulator modifying both epidermal and dermal healing processes after cutaneous wounding
  • is essential for skin development, and acts as regulator of the skin wound healing process
  • is the master regulatory gene of thymic epithelium development
  • FOXN1 expression in the thymic primordium inhibits tubulogenesis and induces the expression of genes involved in TEC differentiation
  • transcription factor essential for thymic epithelial cell (TEC) differentiation
  • CELLULAR PROCESS nucleotide, transcription
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS immunity/defense
    text epidermal development and maintenance
    signaling sensory transduction/vision
    a component
    small molecule
  • keratin
  • HOXC13-dependent activation of FOXN1 is part of a regulatory cascade controlling the expression of terminal differentiation markers
  • pro-differentiation function of RORA is mediated at least in part by FOXN1, a well-known pro-differentiation transcription factor that we establish as a novel direct target of RORA in keratinocytes
  • cell & other
    corresponding disease(s) WHN
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging
    Variant & Polymorphism
    Candidate gene
    Therapy target
  • Nude mice carry a spontaneous mutation affecting the gene Foxn1 mainly expressed in the epidermis