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FLASH GENE
Symbol FOXL1 contributors: mct/npt - updated : 07-11-2009
HGNC name forkhead box L1
HGNC id 3817
Location 16q24.1      Physical location : 86.612.114 - 86.615.303
Synonym name
  • transcriptional factor-like L1
  • forkhead-like 11
  • Synonym symbol(s) FREAC7, FKHL11, FKH6
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text arranged in tandem with FOXC2, FOXF1
    STRUCTURE 3.19 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1609 16q24.1 KIAA1609 protein COTL1 16q24.1 coactosin-like 1 (Dictyostelium) C16orf44 16q24.1 chromosome 16 open reading frame 44 USP10 16q24.1 ubiquitin specific protease 10 DKFZP434B044 16q24.1 hypothetical protein DKFZp434B044 LOC123862 16q24.1 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) ZDHHC7 16q23.3 zinc finger, DHHC domain containing 7 KIAA0513 16q24.1 KIAA0513 gene product FLJ44299 16q24.1 FLJ44299 protein LOC123855 16q24.1 similar to ENSANGP00000013733 MGC22001 16q24.1 hypothetical protein MGC22001 LOC388303 16 LOC388303 LOC388304 16 LOC388304 KIAA0182 16q24 LOC388304 Pfs2 16q24.1 DNA replication complex GINS protein PSF2 NOC4 16q24.3 neighbor of COX4 COX4I1 16q24.2 cytochrome c oxidase subunit IV isoform 1 LOC390744 16 similar to ribosomal protein L10a ICSBP1 16q24.1 interferon consensus sequence binding protein 1 LOC390745 16 similar to hypothetical protein Tb927.2.5760 LOC390746 16 similar to Chloride intracellular channel protein 1 (Nuclear chloride ion channel 27) (NCC27) (p64 CLCP) (Chloride channel ABP) FOXF1 16q24 forkhead box F1 FLJ12998 16q24.1 hypothetical protein FLJ12998 FLJ30679 16q24.1 hypothetical protein FLJ30679 FOXC2 16q24.3 forkhead box C2 (MFH-1, mesenchyme forkhead 1) FOXL1 16q24.3 forkhead box L1 LOC388305 16 LOC388305 MGC15419 16q24.2 MGC15419 protein MAP1LC3B 16q24.1 microtubule-associated protein 1 light chain 3 beta BDG29 16q24.2 BDG-29 proten JPH3 16q24.3 junctophilin 3 DKFZp434G0522 16q24.3 hypothetical protein DKFZp434G0522 SLC7A5 16q24.3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 CA5A 16q24.3 carbonic anhydrase VA, mitochondrial BANP 16q24 carbonic anhydrase VA, mitochondrial LOC388306 16 LOC388306 LOC390747 16 similar to proline rich protein ZNF469 16q24 zinc finger protein 469 ZFPM1 16q24.3 zinc finger protein, multitype 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 3207 - 345 - Pierrou (1994)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text gastro-intestinal mesenchyme
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a forkhead (FH,winged helix) domain
  • two loops-wings on the C terminal side of helix-turn-helix homeo domain
  • HOMOLOGY
    interspecies homolog to Drosophila homeo forkhead
    ortholog to murine Fkh6
    Homologene
    FAMILY
  • HNF-3 forkhead family of transcriptional activator
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • embryonic transcriptional regulator
  • promotes liver repair after bile-duct-ligation-induced liver injury through activation of the canonical WNT/beta-catenin pathway (Sackett 2009)
  • with FOXF1, are mediators of the Hh (endoderm) to mesoderm signaling pathway (Madison 2009)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text embryonic development, essential for the development and differentiation of (gastric) parietal cells
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    fkh6-/- knockout mice