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FLASH GENE
Symbol FOXL1 contributors: mct/npt - updated : 07-11-2009
HGNC name forkhead box L1
HGNC id 3817
Location 16q24.1      Physical location : 86.612.114 - 86.615.303
Synonym name
  • transcriptional factor-like L1
  • forkhead-like 11
    • Synonym symbol(s) FREAC7, FKHL11, FKH6
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text arranged in tandem with FOXC2, FOXF1
    STRUCTURE 3.19 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 3207 - 345 - Pierrou (1994)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text gastro-intestinal mesenchyme
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a forkhead (FH,winged helix) domain
  • two loops-wings on the C terminal side of helix-turn-helix homeo domain
    • HOMOLOGY
    interspecies homolog to Drosophila homeo forkhead
    ortholog to murine Fkh6
    Homologene
    FAMILY
  • HNF-3 forkhead family of transcriptional activator
    • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • embryonic transcriptional regulator
  • promotes liver repair after bile-duct-ligation-induced liver injury through activation of the canonical WNT/beta-catenin pathway (Sackett 2009)
  • with FOXF1, are mediators of the Hh (endoderm) to mesoderm signaling pathway (Madison 2009)
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text embryonic development, essential for the development and differentiation of (gastric) parietal cells
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    fkh6-/- knockout mice