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FLASH GENE
Symbol FOXK2 contributors: mct - updated : 09-11-2013
HGNC name forkhead box K2
HGNC id 6036
Location 17q25.3      Physical location : 80.477.593 - 80.562.481
Synonym name
  • interleukin enhancer binding factor 1
  • winged-helix transcription factor IL-2 enhancer binding factor
  • Synonym symbol(s) ILF, ILF1, ILF-1
    DNA
    TYPE functioning gene
    STRUCTURE 84.90 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text three isoforms (two of them by alternative splicing)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 301 69 655 - 1992 1339390
    9 - 5262 - 660 - 1992 1339390
    - - 2200 - 323 - 1992 1339390
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Lymphoid    
    cell lineage lymphoid and non lymphoid cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two CDK phosphorylation sites, serines 368 and 423, which play a role in defining FOXK2 function through regulating its stability and its activity as a transcriptional repressor protein
  • a forkhead (FH) DNA binding domain homolog
  • winged helix (with two loops-wings on the C-terminal side of helix-turn-helix homeo domain)
  • HOMOLOGY
    interspecies homolog to C.elegans Y24d9a.1
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • is a G/T-mismatch DNA-binding protein and a deaminated DNA-binding protein
  • exhibits a periodic rise in its phosphorylation levels during the cell cycle, with hyperphosphorylation occurring in mitotic cells
  • participates in combinatorial transcriptional control with the AP-1 transcription factor
  • required for the efficient recruitment of AP-1 to chromatin
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binding to interleukin enhancer
  • binding to purine-rich regulatory motif in HIV-1LTR and IL2 promoter
  • bound to G/T-mismatch DNA with higher affinity than 'match' FOXK2 consensus
  • RNA
    small molecule
    protein
  • bound constitutively to the IL2 promoter
  • is subject to control by cell cycle-regulated protein kinases
  • acts to promote AP-1-dependent gene expression changes in response to activation of the AP-1 pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS