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FLASH GENE
Symbol FOXI1 contributors: - updated : 23-05-2007
HGNC name forkhead box I1
HGNC id 3815
Location 5q34      Physical location : 169.532.916 - 169.536.728
Genatlas name transcription factor-like 10
Synonym name
  • HNF-3/fork-head homolog-3
  • forkheaad (Drosophila)-like 10
  • forkhead-related activator 6
  • hepatocyte nuclear factor 3 forkhead homolog 3
  • Synonym symbol(s) FREAC6, KHL10, HFH3, MGC34197
    DNA
    TYPE like-sequence
    STRUCTURE 3.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    ODZ2 5q35.1 odd Oz/ten-m homolog 2 KIBRA 5q35.1 KIBRA protein RARS 5pter-q11 arginyl-tRNA synthetase LOC345630 5q35.1 similar to fibrillarin PANK3 5q35 pantothenate kinase 3 LOC389342 5 similar to 60S ribosomal protein L10 (QM protein homolog) SLIT3 5q35 slit homolog 3 (Drosophila) FLJ20364 5q35.1 hypothetical protein FLJ20364 DOCK2 5q35.1 dedicator of cyto-kinesis 2 FOXI1 5q34 forkhead box I1 LOC345430 5q35.1 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC133874 5q35.1 hypothetical gene LOC133874 LCP2 5q34 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) KCNMB1 5q34 potassium large conductance calcium-activated channel, subfamily M, beta member 1 KCNIP1 5q35.2 Kv channel interacting protein 1 LOC389343 5 LOC389343 GABRP 5q33-q34 gamma-aminobutyric acid (GABA) A receptor, pi RANBP17 5q31 RAN binding protein 17 USP12P1 5q33-q34 ubiquitin specific protease 12 pseudogene 1 TLX3 5q35.1 T-cell leukemia, homeobox 3 LOC391847 5 similar to hypothetical protein LOC391848 5 similar to 60S ribosomal protein L10 (QM protein homolog) NPM1 5q35 nucleophosmin (nucleolar phosphoprotein B23, numatrin) FGF18 5q34 fibroblast growth factor 18 FBXW1B 5q35.1 F-box and WD-40 domain protein 1B STK10 5q35.1 serine/threonine kinase 10 LOC285588 5q35.2 similar to RIKEN cDNA 1700007I06 DC-UbP 5q35.2 dendritic cell-derived ubiquitin-like protein KIAA1295 5q35.2 KIAA1295 protein LOC391849 5 similar to neuralized homolog LOC133539 5q35.2 similar to RIKEN cDNA 1810009O10 DUSP1 5q34 dual specificity phosphatase 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2011 - 283 - Rodriguez-Antona
    - - 2296 - 378 - Rodriguez-Antona
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland  
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney,iotic vesicle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a forkhead (FH, winged helix) domain
  • with two loops-wings on the C-terminal side of helix-turn-helix homeo domain
  • HOMOLOGY
    interspecies homolog to Drosophila homeo forkhead DNA binding domain
    ortholog to murine Fkhl10
    Homologene
    FAMILY HNF-3 forkhead family of transcriptional activator
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • embryonic transcriptional regulator necessary for the development of both cochlea and vestibulum
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text inner ear
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein transcriptional activator of SLC26A4
    cell & other
    REGULATION
    Other maybe associated with the common cavity phenotype
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in Pendred syndrome
    constitutional germinal mutation      
    in hearing loss associated with enlarged vestibular aqueduct (DFNB4)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice with a targetted disruption of Frhl10 have a gross structural malformation of the cochlea and vestibulum replaced by a single irregular cavity