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FLASH GENE
Symbol FOXH1 contributors: mct - updated : 03-10-2006
HGNC name forkhead box H1
HGNC id 3814
Corresponding disease
HPE16 holoprosencephaly 16
Location 8q24.3      Physical location : 145.699.116 - 145.701.718
Synonym name forkhead activin signal transducer 1
Synonym symbol(s) FAST1
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC392277 8 similar to RIKEN cDNA 1700091F14 KIAA1833 8q24.3 hypothetical protein KIAA1833 BOP1 8q24.3 block of proliferation 1 HSF1 8q24.3 heat shock transcription factor 1 DGAT1 8q24.3 diacylglycerol O-acyltransferase homolog 1 (mouse) DKFZp547F072 8q24.3 hypothetical protein DKFZp547F072 SCRT1 8q24.3 scratch homolog 1, zinc finger protein (Drosophila) LOC340393 8q24.3 similar to unnmaed protein product FBXL6 8q24-q25 F-box and leucine-rich repeat protein 6 FLJ11856 8q24.3 putative G-protein coupled receptor GPCR41 ADCK5 8q24.3 aarF domain containing kinase 5 CPSF1 8q24-q23 cleavage and polyadenylation specific factor 1, 160kDa SLC39A4 8q24.3 solute carrier family 39 (zinc transporter), member 4 VPS28 8q24.3 vacuolar protein sorting 28 (yeast) NFKBIL2 8q24.3 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 MGC13010 8q24.3 hypothetical protein MGC13010 KIFC2 8q24.3 likely ortholog of mouse kinesin family member C2 FOXH1 8q24.3 forkhead box H1 PPP1R16A 8q24.3 protein phosphatase 1, regulatory (inhibitor) subunit 16A GPT 8q24.3 glutamic-pyruvate transaminase (alanine aminotransferase) LOC113655 8q24.3 hypothetical protein BC011982 RECQL4 8q24.3 RecQ protein-like 4 KIAA0014 8q24.3 RecQ protein-like 4 LOC389698 8 LOC389698 KIAA1688 8q24.3 KIAA1688 protein LOC90987 MGC10520 RPL8 8q24.3-qter ribosomal protein L8 ZNF517 8q24.3 zinc finger protein 517
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
 male systemtestis   
cell lineage
cell lines several cancer cell lines (ARE)
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a forkhead (FH, winged helix) domain with two loops-wings on the C-terminal side of helix-turn-helix homeo domain
  • HOMOLOGY
    interspecies homolog to Xenopus forkhead activin signal transducer-1
    Homologene
    FAMILY HNF-3 FKH family of transcriptional activators
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • embryonic transcriptional regulator
  • TGF-beta/activin signal transducer
  • regulating NODAL and LEFTB
  • activating the activin response element (ARE) after SMAD4 binding and TGF beta stimulation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text left/right asymetry
    PATHWAY
    metabolism
    signaling signal transduction
    a component complexing with SMAD2, SMAD4
    INTERACTION
    DNA binding to ASE (asymetric enhancers) of NODAL and LEFTB
    RNA
    small molecule
    protein
  • binding to SMAD2
  • physically interacts with SESN1
  • cell & other
    REGULATION
    activated by NODAL through activin receptors ACVR1B,ACVR2,ACVR2B
    ASSOCIATED DISORDERS
    corresponding disease(s) HPE16
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    expressed on both sides of the LPM