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FLASH GENE
Symbol FOXD1 contributors: mct - updated : 07-02-2012
HGNC name forkhead box D1
HGNC id 3802
Location 5q13.2      Physical location : 72.742.086 - 72.744.352
Genatlas name winged helix transcription factor,kidney expression
Synonym name
  • Forkhead, drosophila, homolog-like 8
  • forkhead (Drosophila)-like 8
  • forkhead-related activator 4
  • Synonym symbol(s) FREAC4, FKHL8, HFH-BF-2
    DNA
    TYPE like-sequence
    STRUCTURE 2.27 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC391794 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 PMCHL2 5q13 pro-melanin-concentrating hormone-like 2 BDP1 5q13 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB MCCC2 5q12-q13 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) CART 5q13.1 Homo sapiens cocaine- and amphetamine-regulated transcript (CART), mRNA. MAP1B 5q13 microtubule-associated protein 1B MRPS27 5q13.2 mitochondrial ribosomal protein S27 FLJ12598 5q13.2 hypothetical protein FLJ12598 LOC391795 5 similar to ribosomal protein L10a ZNF366 5q13.1 zinc finger protein 366 LOC389300 5 LOC389300 KPNB2 5p14.2-q22.3 karyopherin (importin) beta 2 LOC115548 5q13.2 hypothetical protein BC014311 LOC134285 5q13.3 hypothetical protein LOC134285 MGC13034 5q13.3 hypothetical protein MGC13034 LOC389301 5 similar to nonhistone chromosomal protein HMG-17 - rat LOC389302 5 LOC389302 FOXD1 5q12-q13 forkhead box D1 BTF3 5p13.2 basic transcription factor 3 LOC220793 5q13.3 similar to hepatitis C virus core-binding protein 6; cervical cancer oncogene 3 ANKRA2 5q12-q13 ankyrin repeat, family A (RFXANK-like), 2 FLJ12787 5q13.3 hypothetical protein FLJ12787 PRO1942 5q13.3 hypothetical protein PRO1942 RGNEF 5q13.3 Rho-guanine nucleotide exchange factor ENC1 5q12-q13.3 ectodermal-neural cortex (with BTB-like domain) HEXB 5q12 hexosaminidase B (beta polypeptide) EFG2 5q13 hexosaminidase B (beta polypeptide) TINP1 5q13.3 TGF beta-inducible nuclear protein 1 KIAA0888 5q13.3 KIAA0888 protein LOC260421 5q13 actin related protein 2/3 complex subunit 1A pseudogene LOC389303 5 hypothetical gene supported by BC039003 LOC391796 5 similar to hypothetical protein FLJ10891 C2GNT3 5q12 similar to hypothetical protein FLJ10891 FLJ40191 5q13.3 hypothetical protein FLJ40191 HMGCR 5q13.3-q14 3-hydroxy-3-methylglutaryl-Coenzyme A reductase COL4A3BP 5q13.1 collagen, type IV, alpha 3 (Goodpasture antigen) binding protein POLK 5q13 polymerase (DNA directed) kappa LOC391797 5 similar to hypothetical protein LOC348094 FLJ35779 5q13.3 hypothetical protein FLJ35779 LOC389304 5 hypothetical gene supported by AK125735 LOC391798 5 similar to importin alpha 1b LOC134356 5q13.3 similar to breast cancer associated protein BRAP1; bridging integrator-2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2272 - 465 - 2004 15509772
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear    
    Skin/Tegumentskin    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text developing kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a forkhead (FH,winged helix) domain with two loops-wings on the C-terminal side of helix-turn-helix homeo domain
  • HOMOLOGY
    interspecies homolog to Drosophila homeo forkhead DNA binding domain
    Homologene
    FAMILY HNF-3 forkhead family of transcriptional activator
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • embryonic transcriptional regulator
  • involved in kidney development
  • plays a dual role in the establishment of the binocular visual pathways: first, in specification of the ventrotemporal retina, acting upstream of proteins directing the ipsilateral pathway, and second, in the patterning of the developing ventral diencephalon where the optic chiasm forms
  • acts as a transcription repressor in controlling its downstream targets in the retina
  • functions as a conserved determinant of temporal identity, and is required for the specification of the temporal retina
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • FOXG1 and FOXD1 are potentially located at the top of the gene cascade for regional specification along the nasotemporal (anteroposterior) axis in the retina
  • a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • PIGF is a direct and physiologically relevant transcriptional target of FOXD1
  • possible interaction between FOXD1 and TFAP2A
  • EPHA6 is a FOXD1 downstream effector that sends temporal axons to the rostral colliculus
  • cell & other
    REGULATION
    Other regulated by ETS1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    results in striking renal abnormalities, including the loss of the discrete zones of induction and differentiation that are crucial to the future radial patterning and pelvic fused kidneys
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS