basic FUNCTION
| embryonic transcriptional regulator, playing a role in adipocyte metabolism by increasing the sensitivity of the beta-adremergic CAMP protein kinase A |
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involved in the specification of the lymphatic capillary versus collecting lymphatic vessel |
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playing a central role in promoting invasion and metastasis and that it may prove to be a highly specific molecular marker for human basal-like breast cancers |
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common transcriptional activator of insulin and TGF-beta signaling to directly regulate SERPINE1 expression via 2 distinct target sites, an insulin response element (IRE) and a novel forkhead-binding element (FBE), adjacent to a SMAD-binding site |
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controls the expression of a distinct set of podocyte genes involved in podocyte differentiation and glomerular basement membrane maturation |
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important regulator of the chemotactic motility of endothelial cells through the induction of CXCR4 expression |
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playing an important role for the normal development and maintenance of venous and lymphatic valves (Mellor 2007) |
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plays a role in conditions such as obesity, dyslipidemia, and type 2 diabetes |
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essential regulator of the cardiovascular system in development and disease |
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regulates angiogenesis via multiple signaling pathways, including ITGB3, CXCR4, and DLL4 |
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implicated in cancer progression through its induction of epithelial-to-mesenchymal transition |
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important metabo-regulator of mitochondrial morphology and metabolism |
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plays an important role in regulation of metabolism, arterial specification, and vascular sprouting |
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plays an important role in osteoblastogenesis by promoting osteoblast proliferation, survival and differentiation through up-regulation of ITGB1 in response to stimuli which induce bone formation |
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FOXC1 and FOXC2 are forkhead transcription factors that play essential roles during development and physiology |
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new role in regulating proliferation and preventing premature differentiation of activated muscle satellite cells |
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forkhead transcription factor that plays an essential role in lymphatic vascular development |
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pivotal role of phosphorylation in the regulation of FOXC2-mediated transcription in lymphatic endothelial cells and importance of FOXC2 phosphorylation in vascular development |
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required for the maintenance of the mesenchymal phenotype after TGFB1 induced EMT in human ovarian cancer cells |