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FLASH GENE

Symbol

FOXB1

contributors: mlc/np - updated : 09-11-2007

HGNC name	forkhead box B1
HGNC id	3799

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q21-q26      Physical location : 60.296.420 - 60.298.142
Synonym name	transcription factor-like 5
Synonym symbol(s)	HFKH5, FKH5

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	1.00 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 1 - 1459 34 324 - Kimura (2006)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive female system uterus       Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	expression in the developing neural tube is soon restricted to the ventral and caudal diencephalon

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a forkhead (FH, winged helix) domain
	two loops-wings on the C-terminal side of helix-turn-helix homeo domain

HOMOLOGY

interspecies

homolog to Drosophila homeo forkhead DNA binding domain

Homologene

FAMILY

HNF-3 FKH forkhead family of transcriptional activator

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION

embryonic transcriptional activator

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS