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FLASH GENE
Symbol FOSL2 contributors: mct - updated : 17-12-2014
HGNC name FOS-like antigen 2
HGNC id 3798
Location 2p23.3      Physical location : 28.615.778 - 28.637.514
Synonym symbol(s) FOSR2, FRA2
DNA
TYPE functioning gene
STRUCTURE 21.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
NRBP 2p23 nuclear receptor binding protein KCP3 SLB 2p23.3 selective LIM binding factor, rat homolog FRCP1 GCKR 2p23.3-p23.2 glucokinase (hexokinase 4) regulatory protein DKFZp434G118 ZNF512 2p23 zinc finger protein 512 FLJ13646 2p23.3 hypothetical protein FLJ13646 XAB1 2p23.3 XPA binding protein 1 STAF65(gamma) 2pter-p25.1 SPTF-associated factor 65 gamma SLC4A1AP 2p23.3 solute carrier family 4 (anion exchanger), member 1, adaptor protein MRPL33 2p22 mitochondrial ribosomal protein L33 RBSK BRE 2p23.3 brain and reproductive organ-expressed (TNFRSF1A modulator) FOSL2 2p23-p22 FOS-like antigen 2 FLJ23306 2p23.3 hypothetical protein FLJ23306 LOC388937 2 similar to Phospholipase PLB PPP1CB 2p23 protein phosphatase 1, catalytic subunit, beta isoform SPY1 2p23.3 speedy FLJ20628 2p23.3 hypothetical protein FLJ20628 KIAA0007 2p23.3 KIAA0007 protein LOC388938 2 LOC388938 LOC165186 2p23.3 similar to RIKEN cDNA 4632412N22 gene LOC388939 2 similar to BC027072 protein FLJ21069 2p23.3 hypothetical protein FLJ21069 ALK 2p23 anaplastic lymphoma kinase (Ki-1)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4015 - 326 - Olsen (2006)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Nervousnerve   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
basic leucine zipper (bZIP) protein
mono polymer heteromer , dimer
HOMOLOGY
Homologene
FAMILY Fos gene family
CATEGORY transcription factor , antigen
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • implicated as regulators of cell proliferation, differentiation, and transformation
  • controling osteoclast survival and size through LIF/LIF-receptor signalling
  • is a basic -leucine zipper (bZIP) motif 'Fos' family transcription factor that is part of the AP1 transcription factor complex and is also known to play a critical role in the progression of human tumours and more recently as a determinant of T cell plasticity
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forming heterodimers, the AP-1 complex with JUN family of proteins
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • SOX4 is a direct target gene of FOSL2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma
  • FOSL2 is a novel STAT5A target gene, regulated by IL2 in activated CD4 T cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in head and neck squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • potential targets for the treatment of syndromes associated with increased osteoclastogenesis
  • ANIMAL & CELL MODELS