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FLASH GENE
Symbol FOPNL contributors: mct - updated : 13-04-2016
HGNC name FGFR1OP N-terminal like
HGNC id 26435
Location 16p13.11      Physical location : -
Synonym name
  • hypothetical protein LOC123811
  • LisH domain-containing protein C16orf63
  • chromosome 16 open reading frame 63
  • FOP-related protein of 20 kDa
  • pluripotent embryonic stem cell-related protein
  • Synonym symbol(s) DKFZp686N1651, FLJ31153, PHSECRG2, FOR20, C16orf63
    DNA
    TYPE functioning gene
    STRUCTURE 22.93 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2342 - 174 - 2013 24018379
    4 - 2144 - 108 - 2013 24018379
    3 - 2120 - 200 - 2013 24018379
    4 - 2205 - 104 - 2013 24018379
    5 - 2277 - 128 - 2013 24018379
    6 - 2414 - 198 - 2013 24018379
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestiveesophagus    
    Lymphoid/Immunelymph node    
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period fetal
    Text umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    basic FUNCTION
  • OFD1 and FOPNL are known to regulate the integrity of the centriole distal end, confirming that this structural element is a target of importance for pathogenic mutations in ciliopathies
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • recruitment of PLK1 to centrosomes by FOPNL may act as a signal to license efficient progression of S-phase
  • directly interacts with OFD1 in the absence of FOPNL, but the interaction between KIAA0753 and OFD1 is much stronger when FOPNL is present in the complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS