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FLASH GENE
Symbol FOLH1 contributors: mct/npt - updated : 25-02-2009
HGNC name folate hydrolase (prostate-specific membrane antigen) 1
HGNC id 3788
Location 11p11.12      Physical location : 49.168.187 - 49.230.222
Synonym name
  • glutamate carboxylase II
  • folate hydrolase, prostate-specific membrane antigen identified by a monoclonal antibody 7E11-C5 (see TSG11A, CD82)
  • pteroylpoly-gamma-glutamate carboxypeptidase
  • N-acetylated alpha-linked acidic dipeptidase 1
  • cell growth-inhibiting protein 27
  • prostate specific membrane antigen variant F
  • Synonym symbol(s) PSM, PSMA, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP
    EC.number 3.4.17.21
    DNA
    TYPE functioning gene
    STRUCTURE 62.04 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   enhancer
    text structure
  • in the third intron, repressed in the presence of androgen
  • the proximal 240 bp of the promoter (232 bp of the 5prime UTR and 8 bp of 5prime untranscribed sequences) may represent the core promoter, and sequences beyond 240 bp may be important for its tissue-specific expression (Han 2007)
  • MAPPING cloned Y linked N status confirmed
    Map pter - D11S986 - D11S1344 - FOLH1 /D11S1357 /D11S1326 - D11S1350 - cen
    Authors Maraj (98)
    Physical map
    LOC119765 11p11.12 similar to Olfactory receptor 4B1 (OST208) LOC390112 11 similar to Olfactory receptor 4B1 (OST208) LOC119764 11p11.12 similar to Olfactory receptor 4X2 LOC390113 11 similar to Olfactory receptor 4X1 LOC256148 11p11.12 similar to Olfactory receptor 4S1 LOC256144 11p11.12 similar to seven transmembrane helix receptor LOC390114 11 similar to olfactory receptor MOR234-3 LOC256143 11p11.12 similar to seven transmembrane helix receptor LOC119750 11p11.12 similar to seven transmembrane helix receptor OR4C10P 11q12.1 olfactory receptor, family 4, subfamily C, member 10 pseudogene OR4C9P 11q12.1 olfactory receptor, family 4, subfamily C, member 9 pseudogene OR4R1P 11q12.1 olfactory receptor, family 4, subfamily R, member 1 pseudogene LOC283101 11p11.12 similar to olfactory receptor MOR231-3 LOC390116 11 similar to olfactory receptor LOC390117 11 similar to olfactory receptor LOC390118 11 similar to olfactory receptor LOC390119 11 similar to Olfactory receptor 4A5 LOC390120 11 similar to RIKEN cDNA 0610012A05 LOC390121 11 similar to RIKEN cDNA 0610012A05 LOC144147 11p11.12 similar to RING finger protein 18 (Testis-specific ring-finger protein) LOC120824 11p11.12 similar to RING finger protein 18 (Testis-specific ring-finger protein) LOC340970 11p11.12 similar to tripartite motif-containing 43 LOC283116 11p11.12 similar to RING finger protein 18 (Testis-specific ring-finger protein) LOC283117 11p11.12 similar to tripartite motif-containing 43 LOC196346 11p11.12 similar to autoantigen NOR-90 LOC120123 11p11.12 similar to surface glycoprotein, Ig superfamily member LOC390122 11 similar to tripartite motif-containing 43 FOLH1 11p11.2 folate hydrolase (prostate-specific membrane antigen) 1 LOC283247 11p11.12 similar to NADPH oxidase 4 variant TYRL 11p11.2 tyrosinase-like LOC387767 11 similar to mitochondrial carrier protein MGC4399 LOC387768 11 similar to Metabotropic glutamate receptor 5 precursor (mGluR5) LOC283257 11p11.12 similar to RING finger protein 18 (Testis-specific ring-finger protein) LOC390123 11 similar to RIKEN cDNA 0610012A05 LOC390124 11 similar to hypothetical protein FLJ14082 LOC390125 11 similar to RIKEN cDNA 0610012A05 OR4A1P 11q23.3 olfactory receptor, family 4, subfamily A, member 1 pseudogene LOC390126 11 similar to Olfactory receptor 4A4 LOC283092 11p11.12 similar to Olfactory receptor 4C13 LOC283093 11p11.12 similar to Olfactory receptor 4C12 LOC390127 11 similar to seven transmembrane helix receptor LOC390128 11 similar to olfactory receptor MOR234-3 LOC390129 11 similar to seven transmembrane helix receptor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 2653 84.2 750 - Barinka (2008)
    18 - 2560 80.5 719 - Barinka (2008)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Lymphoid/Immunespleen   highly
    Nervousbrain    
    Reproductivemale systemprostate  highly
    Urinarykidney    
    cell lineage
    cell lines neoplastic prostatic cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal membrane spanning region
  • a catalytic region of 313AA with two catalytic zinc atoms
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to porcine FGCP
    homolog to rattus Naaladase
    Homologene
    FAMILY
  • glutamate carboxypeptidase family
  • peptidase family M28
  • CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text type II transmembrane protein
    basic FUNCTION
  • folate hydrolase and NAALAdase activity
  • involved in conversion of the major neurotransmitter (NAAG) to NAA and free glutamate
  • acting as a glutamate carboxypeptidase (Giusti 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in metastatic prostatic carcinoma
    Susceptibility
  • to cardiovascular disease (CVD)
  • to abdominal aortic aneurysm (Giusti 2008)
  • Variant & Polymorphism other 1561C-->T polymorphism may affect the predisposition to CVD.
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS