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FLASH GENE
Symbol FNTB contributors: mct - updated : 22-06-2018
HGNC name farnesyltransferase, CAAX box, beta
HGNC id 3785
Location 14q23.3      Physical location : 65.453.506 - 65.529.369
Synonym name
  • FTase-beta
  • CAAX farnesyltransferase subunit beta;
    • Synonym symbol(s) FPTB, MGC31935
    EC.number 2.5.1.581
    DNA
    TYPE functioning gene
    STRUCTURE 75.86 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure a CAAX box in the promoter
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2894 - 498 - 2011 21268067
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Nervousbrain   highly
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		five PFTB repeats
    HOMOLOGY
    Homologene
    FAMILY protein prenyltransferase beta subunit family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • promoting the prenylation of Ras, first step of a series of post translational modification of RAS
  • required for its association with the inner surface of the plasma membrane
  • also involved in maturation of other proteins including Ras family members, the gamma subunit of G proteins and nuclear lamins
  • enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif (
  • with HDAC6 are present in a protein complex together with microtubules
  • via its tubulin-association, is a critical upstream regulator of HDAC6 activity and its expression could help stratify cancer patients that would most benefit from this treatment
  • FNTB and PGGT1B are required for the homeostasis of skin keratinocytes
  • is not dispensable and PPGT1B is crucial for the vitality of hepatocytes
  • catalyzes the biologically relevant lipidation of up to several hundred cellular proteins (PMUD: 22992747)
  • FNTB signaling plays a significant role in acute pancreatitis (AP) by regulating neutrophil infiltration and tissue injury via the neutrophil expression of macrophage-1 antigen
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • farnesyltransferase is an heterodimer of an alpha and a beta subunit (FNTA, FNTB)
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 1 zinc ion per subunit
    protein
    cell & other
  • binds microtubules directly via its alpha subunit, and this association requires the C terminus of tubulin
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestive  
    might constitute a target in the management of severe acute pancreatitis (AP)
    ANIMAL & CELL MODELS
  • hepatocyte-specific Fntb knockout mice survived but exhibited hepatocellular disease and elevated transaminases