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FLASH GENE
Symbol FNTA contributors: mct - updated : 21-06-2018
HGNC name farnesyltransferase, CAAX box, alpha
HGNC id 3782
Location 8p11.21      Physical location : 42.911.441 - 42.940.923
Synonym name
  • protein prenyltransferase alpha subunit repeat containing 2
  • type I protein geranyl-geranyltransferase subunit alpha
  • Ras proteins prenyltransferase alpha
  • CAAX farnesyltransferase subunit alpha
  • farnesyltransferase (FTase)
  • Synonym symbol(s) FPTA, PGGT1A, PTAR2, MGC99680, FTase
    EC.number 2.5.1.58, 2.5.1.59
    DNA
    TYPE functioning gene
    STRUCTURE 29.49 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure a CAAX box in the promoter
    MAPPING cloned Y linked N status confirmed
    Physical map
    SFRP1 8p12-p11.2 secreted frizzled-related protein 1 GCP16 LOC392214 8 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MGC14799 8p11.21 hypothetical protein MGC14799 DKFZp586M1819 8p11.21 putative lysophosphatidic acid acyltransferase FLJ25169 8p11.21 hypothetical protein FLJ25169 ANK1 8p11.2 ankyrin 1, erythrocytic MYST3 8p11 MYST histone acetyltransferase (monocytic leukemia) 3 AP3M2 8p11.2 adaptor-related protein complex 3, mu 2 subunit PLAT 8p12-p11.2 plasminogen activator, tissue LOC389650 8 LOC389650 IKBKB 8p11.2 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta POLB 8p11.2 polymerase (DNA directed), beta DKK4 8p11.2-p11.1 dickkopf homolog 4 (Xenopus laevis) VDAC3 8q11.2 voltage-dependent anion channel 3 SLC20A2 8p12-q21 solute carrier family 20 (phosphate transporter), member 2 LOC114926 8p11.21 hypothetical protein BC013035 CHRNB3 8p11.2 cholinergic receptor, nicotinic, beta polypeptide 3 CHRNA6 8p22 cholinergic receptor, nicotinic, alpha polypeptide 6 THAP1 8p11.1 THAP domain containing, apoptosis associated protein 1 DKFZP564A022 8p11.21 hypothetical protein DKFZp564A022 HOOK3 8p11.21 hook homolog 3 (Drosophila) FNTA 8p22-q11 farnesyltransferase, CAAX box, alpha FLJ23356 8p11.21 hypothetical protein FLJ23356 FLJ32731 8p11.1 hypothetical protein FLJ32731 LOC347028 8p11.21 similar to AFG3-like protein 2 (Paraplegin-like protein) LOC340441 8p11.21 similar to pote protein; Expressed in prostate, ovary, testis, and placenta LOC389651 8 similar to hypothetical protein (L1H 3 region) - human
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 1710 44.3 379 - 2009 19228685
    8 splicing 1624 34.6 288 - 2009 19228685
  • lacking an alternate exon in the 5' coding region compared to variant 1
  • using a frame-shifted downstream start codon compared to variant 1
  • 7 splicing 1509 36.4 312 - 2009 19228685
  • lacking two alternate exons in the 5' coding region compared to variant 1
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestivestomach   moderately
    Endocrineneuroendocrinepituitary  moderately
     parathyroid   highly
     thyroid   moderately
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   moderately
    Nervousnerve   highly
    Skin/Tegumentskin   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five PFTA repeats
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Fnta (92.8 pc)
    homolog to murine Fnta (92.6 pc)
    Homologene
    FAMILY
  • protein premyltransferase alpha subunit family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X
  • promoting the prenylation of Ras
  • first step of a series of post translational modification of RAS
  • attachment of an isoprenoid lipid (a process termed prenylation) by FNTA or geranylgeranyltransferase type I (PGGT1B) is essential for the function of many signal transduction proteins involved in growth, differentiation, and oncogenesis
  • required for its association with the inner surface of the plasma membrane
  • also involved in maturation of other proteins including Ras familymembers, the gamma subunit of G proteins and nuclear lamins
  • acting as an acetylcholine receptor regulator
  • mediates posttranslational modification of proteins with isoprenoid lipids
  • functions of FNTA subunit that includes control of intracellular membrane trafficking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
  • neurotransmitter receptor metabolic process
  • protein amino acid farnesylation
  • protein amino acid geranylgeranylation
  • transforming growth factor beta receptor signaling pathway
  • a component
  • farnesyltransferase is an heterodimer of an alpha and a beta subunit (FNTA, FNTB)
  • participating in a stable complex with the substrate
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • via its tubulin-association, is a critical upstream regulator of HDAC6 activity and its expression could help stratify cancer patients that would most benefit from this treatment (Zhou 2009)
  • VPS4A was validated for direct binding to the FNTA subunit
  • cell & other
    REGULATION
    inhibited by by caspase-3 cleavage of the common alpha subunit during apoptosis (Kim 2001)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS