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FLASH GENE
Symbol FNTA contributors: mct - updated : 21-06-2018
HGNC name farnesyltransferase, CAAX box, alpha
HGNC id 3782
Location 8p11.21      Physical location : 42.911.441 - 42.940.923
Synonym name
  • protein prenyltransferase alpha subunit repeat containing 2
  • type I protein geranyl-geranyltransferase subunit alpha
  • Ras proteins prenyltransferase alpha
  • CAAX farnesyltransferase subunit alpha
  • farnesyltransferase (FTase)
    • Synonym symbol(s) FPTA, PGGT1A, PTAR2, MGC99680, FTase
    EC.number 2.5.1.58, 2.5.1.59
    DNA
    TYPE functioning gene
    STRUCTURE 29.49 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure a CAAX box in the promoter
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 1710 44.3 379 - 2009 19228685
    8 splicing 1624 34.6 288 - 2009 19228685
  • lacking an alternate exon in the 5' coding region compared to variant 1
  • using a frame-shifted downstream start codon compared to variant 1
    • 7 splicing 1509 36.4 312 - 2009 19228685
  • lacking two alternate exons in the 5' coding region compared to variant 1
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestivestomach   moderately
    Endocrineneuroendocrinepituitary  moderately
     parathyroid   highly
     thyroid   moderately
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   moderately
    Nervousnerve   highly
    Skin/Tegumentskin   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five PFTA repeats
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Fnta (92.8 pc)
    homolog to murine Fnta (92.6 pc)
    Homologene
    FAMILY
  • protein premyltransferase alpha subunit family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X
  • promoting the prenylation of Ras
  • first step of a series of post translational modification of RAS
  • attachment of an isoprenoid lipid (a process termed prenylation) by FNTA or geranylgeranyltransferase type I (PGGT1B) is essential for the function of many signal transduction proteins involved in growth, differentiation, and oncogenesis
  • required for its association with the inner surface of the plasma membrane
  • also involved in maturation of other proteins including Ras familymembers, the gamma subunit of G proteins and nuclear lamins
  • acting as an acetylcholine receptor regulator
  • mediates posttranslational modification of proteins with isoprenoid lipids
  • functions of FNTA subunit that includes control of intracellular membrane trafficking
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
  • neurotransmitter receptor metabolic process
  • protein amino acid farnesylation
  • protein amino acid geranylgeranylation
  • transforming growth factor beta receptor signaling pathway
    • a component
  • farnesyltransferase is an heterodimer of an alpha and a beta subunit (FNTA, FNTB)
  • participating in a stable complex with the substrate
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • via its tubulin-association, is a critical upstream regulator of HDAC6 activity and its expression could help stratify cancer patients that would most benefit from this treatment (Zhou 2009)
  • VPS4A was validated for direct binding to the FNTA subunit
    • cell & other
    REGULATION
    inhibited by by caspase-3 cleavage of the common alpha subunit during apoptosis (Kim 2001)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS