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FLASH GENE
Symbol FNIP1 contributors: mct - updated : 03-12-2010
HGNC name folliculin interacting protein 1
HGNC id 29418
Location 5q31.1      Physical location : 130.977.406 - 131.132.756
Synonym symbol(s) KIAA1961, MGC667, DKFZp686E18167, DKFZp781P0215
DNA
TYPE functioning gene
STRUCTURE 155.35 kb     17 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 6655 - 1166 - 2006 17028174
17 - 6571 - 1138 - 2006 17028174
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Reproductivefemale systemplacenta  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION having an important function in modulating energy/nutrient-sensing signaling pathways
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
energy/nutrient-sensing signaling pathways
a component
  • part of of FLCN-AMPK-FNIP complex which is regulated by Ser62 phosphorylation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with FLCN, through the C-terminus of FLCN, and colocalize in the cytoplasm
  • FLCN-GABARAP association is modulated by the presence of either folliculin-interacting protein FNIP1 or FNIP2 and further regulated by ULK1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS