basic FUNCTION
| type I membrane protein that is processed proteolytically to form a newly identified hormone secreted into the blood, termed irisin |
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Irisin is induced in exercise and activates profound changes in the subcutaneous adipose tissue |
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its action recapitulates some of the most important benefits of exercise and muscle activity |
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activation of browning and thermogenic genes by FNDC5 is a major part of the action of this polypeptide on these cells |
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induces browning of white adipose tissues and protects against diet-induced obesity and diabetes |
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is not only a myokine but also an adipokine |
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determines insulin sensitivity in humans |
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may play a major role in affecting high-density lipoprotein cholesterol levels and abnormal energy expenditure in chronic kidney disease patients |
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positively linked to muscle mass, strength and metabolism, pointing to common regulatory factors and/or the potential for irisin to modify muscle phenotype |
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muscle-derived hormone stimulating thermogenesis |
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exercise-induced irisin secretion could have evolved from shivering-related muscle contraction, serving to augment brown fat thermogenesis in concert with FGF21 |
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is a novel myokine produced by skeletal muscle |