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FLASH GENE
Symbol FNBP4 contributors: mct/npt - updated : 15-01-2010
HGNC name formin binding protein 4
HGNC id 19752
Location 11q11.2      Physical location : 47.738.069 - 47.788.993
Synonym symbol(s) KIAA1014, FBP30, DKFZp686M14102, DKFZp779I1064, FLJ41904
DNA
TYPE functioning gene
STRUCTURE 50.92 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ZNF289 11p11.2-p11.12 zinc finger protein 289, ID1 regulated PACSIN3 11p12-p11.2 protein kinase C and casein kinase substrate in neurons 3 DDB2 11p12-p11.2 damage-specific DNA binding protein 2, 48kDa ACP2 11p11.2 acid phosphatase 2, lysosomal NR1H3 11p11.2 nuclear receptor subfamily 1, group H, member 3 MADD 11p11.22-p11.21 MAP-kinase activating death domain MYBPC3 11p11.2 myosin binding protein C, cardiac SPI1 11p12 spleen focus forming virus (SFFV) proviral integration oncogene spi1 SLC39A13 11p11.2 solute carrier family 39 (zinc transporter), member 13 PSMC3 11p13-p12 proteasome (prosome, macropain) 26S subunit, ATPase, 3 RAPSN 11p11.2-p11.1 receptor-associated protein of the synapse, 43kD CUGBP1 11p11 CUG triplet repeat, RNA binding protein 1 KBTBD4 11p11.2 kelch repeat and BTB (POZ) domain containing 4 NDUFS3 11p11.11 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) C1QTNF4 11q11 C1q and tumor necrosis factor related protein 4 MTCH2 11p11.2 mitochondrial carrier homolog 2 (C. elegans) FLJ23598 11p11.2 hypothetical protein FLJ23598 FNBP4 11q12.1 formin binding protein 4 NUP160 11q12.1 nucleoporin 160kDa PTPRJ 11p11.2 protein tyrosine phosphatase, receptor type, J LOC119765 11p11.12 similar to Olfactory receptor 4B1 (OST208) LOC390112 11 similar to Olfactory receptor 4B1 (OST208) LOC119764 11p11.12 similar to Olfactory receptor 4X2 LOC390113 11 similar to Olfactory receptor 4X1 LOC256148 11p11.12 similar to Olfactory receptor 4S1 LOC256144 11p11.12 similar to seven transmembrane helix receptor LOC390114 11 similar to olfactory receptor MOR234-3 LOC256143 11p11.12 similar to seven transmembrane helix receptor LOC119750 11p11.12 similar to seven transmembrane helix receptor OR4C10P 11q12.1 olfactory receptor, family 4, subfamily C, member 10 pseudogene OR4C9P 11q12.1 olfactory receptor, family 4, subfamily C, member 9 pseudogene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 4127 - 1017 - Colland (2004)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two WW domains
  • Pro-Arg motif often overlaping with SH3 domain motifs within protein sequences (Bedford 2000)
  • HOMOLOGY
    interspecies homolog to murine Fnbp4
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • ca compete with AblSH3 domain
  • can perform function similar to SH3 domains
  • might regulate SH3 interactions with target proteins
  • TP53-regulated molecule whose WW domains bind to Pro-Arg-rich cellular proteins (Bedford 2000)
  • its expression is indirectly regulated by TP53, through downregulation of a labile inhibitor of FNBP4 expression (Depraetere 1999)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds with high affinity to proline-rich sequences similar to SH3 ligands
  • interact with formin
  • interacting with KHDRBS1, through its WW domain (Bedford 2000)
  • cell & other
    REGULATION
    Other up-regulated by p53 in thymocytes undergoing programmed cell death
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS