SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,nucleus
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text
| FBP17/MLL fusion gene only in the nucleus |
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FBP17 only in the cytoplasm (directly binds to microtubules) |
basic FUNCTION
| inducing neurite branching in response to ARHN |
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regulating endocytosis by forming vesicotubular structures and involved in dynamin-mediated endocytosis in both a clathrin-dependent and -independent manner |
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recruits WAS, WIPF1, and dynamin-2 to the plasma membrane and that this recruitment is necessary for the formation of podosomes and phagocytic cups (Tsuboi 2009) |
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facilitates membrane deformation and actin polymerization to occur simultaneously at the same membrane sites, which mediates a common molecular step in the formation of podosomes and phagocytic cups (Tsuboi 2009) |
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stimulating curvature-dependent actin polymerization with WAS-WIPF complex (Takano 2008) |
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recruited to clathrin-coated pits in the late stage of clathrin-mediated endocytosis, indicating its physiological role (Shimada (2007) |
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has a critical role in the process of bladder tumor cell invasion by mediating invadopodia formation |
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FNBP1 and RND2 cooperatively regulate spine density |
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plays a key role in spine formation through the regulation of membrane dynamics |
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has emerged as a crucial factor linking the plasma membrane to WAS-mediated actin polymerization |
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self-assembly of FNBP1 at the podosomal membrane initiates actin polymerization, whereas the clustering of PSTPIP2 has an opposite effect |