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FLASH GENE
Symbol FMR1NB contributors: mct - updated : 05-06-2020
HGNC name fragile X mental retardation 1 neighbor
HGNC id 26372
Location Xq27.3      Physical location : 147.062.848 - 147.108.187
Synonym name
  • sarcoma antigen NY-SAR-35
  • cancer/testis antigen 37
  • Synonym symbol(s) FLJ25736, NY-SAR-35, CT37, NYSAR35
    DNA
    TYPE functioning gene
    STRUCTURE 45.33 kb     6 Exon(s)
    regulatory sequence Promoter
    text structure
  • activated by hypomethylation of the CpG island in the gene promoter
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1011 - 255 - 2016 26648093
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte Homo sapiens
    Reproductivespermatogonia Homo sapiens
    cell lineage
    cell lines sarcoma, melanoma, esophageal cancer, lung cancer and breast cancer
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text
  • predominantly expressed at the cytoplasm
  • basic FUNCTION
  • potential target for cancer vaccines and monoclonal antibody-based immunotherapies
  • testis proteins, FMR1NB, NXF2, MAGEA5, FSIP1, and STARD6, are required for accurate chromosome segregation in tumor cells
  • cancer/testis antigen enhanced cell proliferation and invasion
  • functions as a cancer/testis (CT) antigen that triggers oncogenesis and self-renewal
  • increases cancer cell viability, proliferation, migration and invasion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    activated by hypomethylation in cancer cells
    constitutional     --low  
    in fertilization failure (FF), occurring in intracytoplasmic sperm injection (ICSI) cycles
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS