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FLASH GENE
Symbol FMOD contributors: mct - updated : 30-08-2008
HGNC name fibromodulin
HGNC id 3774
Location 1q32.1      Physical location : 203.309.752 - 203.320.289
Synonym name
  • fibromodulin proteoglycan
  • Synonym symbol(s) FM, SLRR2E
    DNA
    TYPE functioning gene
    STRUCTURE 10.00 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HSPC150 1q32.1 HSPC150 protein similar to ubiquitin-conjugating enzyme PPP1R12B 1q32.1 protein phosphatase 1, regulatory (inhibitor) subunit 12B HCP4 1q32.1 cytochrome c, somatic pseudogene SYT2 1q31.3 synaptotagmin II PLU-1 1q32.1 putative DNA/chromatin binding motif LOC388727 1 LOC388727 LOC163556 1q32.1 similar to RIKEN cDNA 4931440L10 LOC391152 1 similar to Tubulin alpha-2 chain (Alpha-tubulin 2) LOC388728 1 similar to alpha tubulin LOC391153 1 similar to actin RABIF 1q32-q41 RAB interacting factor C3IP1 1q32.1 kelch-like protein C3IP1 ADIPOR1 1p36.13-q41 adiponectin receptor 1 CYB5R1 1p36.13-q41 cytochrome b5 reductase 1 (B5R.1) LOC391154 1 similar to hypothetical protein 4933406M09 C1orf37 1q31.1 chromosome 1 open reading frame 37 PPFIA4 1q32.1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 MYOG 1q31-q41 myogenin (myogenic factor 4) ADORA1 1q32.1 adenosine A1 receptor MYBPH 1q32.1 myosin binding protein H CHI3L1 1q31-q32 chitinase 3-like 1 (cartilage glycoprotein-39) CHIT1 1q31-q32 chitinase 1 (chitotriosidase) LOC388729 1 LOC388729 BTG2 1q32 BTG family, member 2 FMOD 1q32.1 fibromodulin ATP2B4 1q32 ATPase, Ca++ transporting, plasma membrane 4 MGC5457 1q32.1 hypothetical protein MGC5457 LAX 1q32.1 hypothetical protein FLJ20340 KIAA0663 1q32.1 hypothetical protein FLJ20340 SNRPE 1q32 small nuclear ribonucleoprotein polypeptide E LOC391155 1 similar to KRT8 protein FLJ40343 1q32.1 hypothetical protein FLJ40343 SOX13 1q31.3-q32.1 SRY (sex determining region Y)-box 13 FLJ10761 1q32.1 putative ethanolamine kinase REN 1q32 renin KISS1 1q32 KiSS-1 metastasis-suppressor FLJ42654 1q32.1 FLJ42654 protein PEPP3 1q32.1 phosphoinositol 3-phosphate-binding protein-3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3005 - 376 - Velez-Delvalle (2008)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Reproductivefemale systembreastmammary gland highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Connectivecartilage   
    Connectivedenseligament  
    Connectivedensetendon  
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten leucine-rich repeats
  • flanked by cysteine-rich regions
  • a N-linked glycosylation site (NKSIT) motifs) in the LRR region
  • HOMOLOGY
    Homologene
    FAMILY
  • Small leucine rich proteoglycan family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix (ECM)
    basic FUNCTION
  • may be having a primary role in collagen fibrillogenesis
  • playing a role in the pathobiology of B-CLL and Mantle Cell Lymphoma
  • small leucine-rich proteoglycan that has a central role in the maintenance of collagen fibrils structure, and in regulation of TGFB biological activity
  • ROR1 and FMOD may be involved in the survival of CLL cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component small collagen-binding proteoglycan constituent of the extra-cellular matrix
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding collagen fibrils types I and II
  • negatively regulating TGFB activities
  • binding keratan sulfate chain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in B-cell chronic lymphocytic leukemia, and in mantle cell lymphoma, compared to normal blood B cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS