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FLASH GENE
Symbol FMO3 contributors: mct - updated : 24-01-2009
HGNC name flavin containing monooxygenase 3
HGNC id 3771
Corresponding disease
TMA trimethylaminuria
Location 1q24.3      Physical location : 171.060.017 - 171.086.957
Synonym symbol(s) FMOII, MGC34400
EC.number 1.14.13.8
DNA
TYPE like-sequence
SPECIAL FEATURE arranged in tandem, component of a cluster
STRUCTURE 26.92 kb     9 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
cytosine-phosphate-guanine/HTF
Binding site
text structure NFY, USF1, an unidentified GC box binding protein, and YY1 appear to play major roles regulating constitutive FMO3 transcription (Klick 2007)
MAPPING cloned Y linked N status confirmed
Map cen - D1S210 - D1S1715 - FMO3 - D1S1542 - D1S815 - qter
Physical map
SELL 1q23.2-q23.3 selectin L (lymphocyte adhesion molecule 1) SELE 1q23.2-q23.1 selectin E (endothelial adhesion molecule 1) MGC9084 1q23.3 hypothetical protein MGC9084 FLJ10706 1q23.3 hypothetical protein FLJ10706 PACE-1 1q23.3 ezrin-binding partner PACE-1 KIFAP3 1q23.2 kinesin-associated protein 3 MRPS10P1 1q23.2 mitochondrial ribosomal protein S10 pseudogene 1 LOC149281 1q23.3 similar to AD-003 protein LOC388713 1 LOC388713 FLJ11752 1q23.3 NTKL-binding protein 1 PRRX1 1q23-1q25 paired related homeobox 1 LOC391133 1 similar to hypothetical protein BC015183 FMO3 1q23-q24 flavin containing monooxygenase 3 LOC388714 1 similar to Putative dimethylaniline monooxygenase [N-oxide forming] 6 (Flavin-containing monooxygenase 6) (FMO 6) (Dimethylaniline oxidase 6) FMO2 1q23-q25 flavin containing monooxygenase 2 FMO1 1q23-q25 flavin containing monooxygenase 1 PRO1257 1q24.1 hypothetical protein PRO1257 FMO4 1q23-q25 flavin containing monooxygenase 4 HCP3 1q23.3 cytochrome c, somatic pseudogene XTP2 1q23.3 HBxAg transactivated protein 2 MYOC 1q24.3-q25.2 myocilin, trabecular meshwork inducible glucocorticoid response LOC391134 1 similar to Chain  , Profilin LOC391135 1 similar to ribosomal protein L4; 60S ribosomal protein L4; homologue of Xenopus ribosomal protein L1 VAMP4 1q24-q25 vesicle-associated membrane protein 4 LOC391136 1 similar to RNA binding motif protein 3 CGI-01 1q24-q25.3 CGI-01 protein LOC391137 1 similar to dJ612B18.1 (similar to 40S ribosomal protein) LOC127099 1q24.1 similar to 60S ACIDIC RIBOSOMAL PROTEIN P1 KIAA0820 1q24 similar to 60S ACIDIC RIBOSOMAL PROTEIN P1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2053 - 532 - Alfieri (2008)
9 - 2070 - 532 - Alfieri (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Urinarykidney    
Visualeyeuveachoroid  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebonesubchondral  
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY FMO family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,cytosolic,microsome
basic FUNCTION
  • converts fishy-smelling trimethylamine (TMA) into odorless trimethylamine-N-oxide (TMAO) (Teresa 2006)
  • involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    FAD
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TMA
    Susceptibility to trimethylaminuria
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS