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FLASH GENE
Symbol FMO3 contributors: mct - updated : 24-01-2009
HGNC name flavin containing monooxygenase 3
HGNC id 3771
Corresponding disease
TMA trimethylaminuria
Location 1q24.3      Physical location : 171.060.017 - 171.086.957
Synonym symbol(s) FMOII, MGC34400
EC.number 1.14.13.8
DNA
TYPE like-sequence
SPECIAL FEATURE arranged in tandem, component of a cluster
STRUCTURE 26.92 kb     9 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
cytosine-phosphate-guanine/HTF
Binding site
text structure NFY, USF1, an unidentified GC box binding protein, and YY1 appear to play major roles regulating constitutive FMO3 transcription (Klick 2007)
MAPPING cloned Y linked N status confirmed
Map cen - D1S210 - D1S1715 - FMO3 - D1S1542 - D1S815 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2053 - 532 - Alfieri (2008)
9 - 2070 - 532 - Alfieri (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Urinarykidney    
Visualeyeuveachoroid  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebonesubchondral  
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY FMO family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,cytosolic,microsome
basic FUNCTION
  • converts fishy-smelling trimethylamine (TMA) into odorless trimethylamine-N-oxide (TMAO) (Teresa 2006)
  • involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    FAD
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TMA
    Susceptibility to trimethylaminuria
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS