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FLASH GENE
Symbol FLRT2 contributors: mct - updated : 25-10-2018
HGNC name fibronectin leucine rich transmembrane protein 2
HGNC id 3761
Location 14q31.3      Physical location : 85.996.487 - 86.094.269
Synonym name
  • platelet glycoprotein 1b,alpha like gene,isolated from brain cDNA libraries
  • fibronectin-like domain-containing leucine-rich transmembrane protein
    • 2
    Synonym symbol(s) KIAA0405, GP1BAL, UNQ232/PRO265
    DNA
    TYPE functioning gene
    STRUCTURE 97.78 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 7185 74 660 - 1999 10644439
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text widely expressed in the developing embryo, particularly highly expressed initially in the cranial neural crest cells, and later expressed in the developing pharyngeal region
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten leucine rich repeats
  • N and C terminal cysteine rich regions
  • one fibronectin-collagen-like domains
  • a transmembrane segment (TM1)
  • an intracellular tail
    • conjugated GlycoP
    HOMOLOGY
    intraspecies paralog to FLRT1
    paralog to FLRT3
    Homologene
    FAMILY
  • fibronectin leucine rich transmembrane protein (FLRT) family
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type I membrane protein
    basic FUNCTION
  • functioning in cell adhesion and/or receptor signaling
  • FLRT1, FLRT2, FLRT3 have a dual role, promoting FGF signalling and modulating homotypic cell adhesion
  • FLRT proteins act potentially as regulators of FGF signalling, being induced by the signal and then able to interact with the signalling receptor, in many tissues (
  • important roles for FLRT2 and FLRT3 in mediating events such as neural crest cell migration, chondrogenesis and epithelial-mesenchymal interactions during craniofacial development
  • having dual properties as regulators of cell adhesion and potentiators of fibroblast growth factor (FGF) mediated signalling
  • FLRT2 or FLRT3 are potentially required in the epicardium to promote heart morphogenesis
  • plays a role in mediating cell proliferation and cell-cell interactions during early chondrogenesis
  • role of FLRT2 in enhancing cell proliferation and reducing intercellular adhesion during the early stages of chondrogenesis
  • FLRT2, FLRT3 are required for the proper distribution of interneurons within the cortical migratory streams and for the final laminar allocation in the postnatal cortex
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of extracellular matrix
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with UNC5D (FLRT2/UNC5D signalling modulates cortical neuron migration)
  • UNC5D interacts with FLRT2 in cis, controlling cell adhesion in response to externally presented
  • ADGRL2 ligands, such as FLRT2, may be therapeutically exploited to interfere with cancer metastatic dissemination
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse embryos lacking Flrt2 expression arrest at mid-gestation owing to cardiac insufficiency