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FLASH GENE
Symbol FLRT1 contributors: mct - updated : 02-11-2011
HGNC name fibronectin leucine rich transmembrane protein 1
HGNC id 3760
Location 11q13.1      Physical location : 63.871.361 - 63.886.645
Synonym name
  • fibronectin-like domain-containing leucine-rich transmembrane protein
    • 1
    Synonym symbol(s) MGC21624, UNQ752/PRO1483
    DNA
    TYPE functioning gene
    STRUCTURE 15.28 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3252 74 674 - 2010 20421966
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten leucine rich repeats
  • N and C terminal cysteine rich regions
  • two fibronectin-collagen-like domains
  • a transmembrane segment (TM1)
  • an intracellular tail
    • conjugated GlycoP
    HOMOLOGY
    intraspecies paralog to FLRT2
    paralog to FLRT3
    Homologene
    FAMILY
  • fibronectin leucine rich transmembrane protein (FLRT) family
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type I membrane protein
    basic FUNCTION
  • functioning in cell adhesion and/or receptor signaling
  • FLRT1, FLRT2, FLRT3 have a dual role, promoting FGF signalling and modulating homotypic cell adhesion
  • FLRT proteins act potentially as regulators of FGF signalling, being induced by the signal and then able to interact with the signalling receptor, in many tissues
  • having dual properties as regulators of cell adhesion and potentiators of fibroblast growth factor (FGF) mediated signalling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of extracellular matrix
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target for tyrosine phosphorylation mediated by FGFR1 and implicate a non-receptor Src family kinase (SFK)
    • cell & other
    REGULATION
    Other phosphorylation state of FLRT1, which is itself FGFR1 dependent, may play a critical role in the potentiation of FGFR1 signalling and may also depend on a SFK-dependent phosphorylation mechanism acting via the FGFR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS