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FLASH GENE
Symbol FLOT2 contributors: mct - updated : 21-11-2014
HGNC name flotillin 2
HGNC id 3758
Location 17q11.2      Physical location : 27.206.357 - 27.224.715
Synonym name
  • membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)
  • flotillin 2, distinct from the ECS-1 antigen ESA
  • epidermal surface antigen
  • reggie-1
    • Synonym symbol(s) ECS1, REGGIE1, ESA, ESA1, M17S1
    DNA
    TYPE functioning gene
    STRUCTURE 18.36 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - FLOT2 - NF1 NF1 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2659 47 428 - 2007 17482312
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • integral membrane protein with a Epb72 domain
    • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • EPB72/stomatin family
  • band 7/mec-2 family
  • flotillin subfamily
    • CATEGORY chaperone/stress , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • resident integral membrane protein of caveolae from epithelial surface
  • associated with membrane rafts
  • localized in microdomains different from caveolae, and the function of reggies is different from and independent of caveolin-1
    • basic FUNCTION
  • involved in cell adhesion
  • may act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles
  • binds to MARK2, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may thereby influence tumor progression
  • defining structural components of the machinery that mediates a clathrin-independent endocytic pathway
  • may be involved in epidermal cell adhesion and epidermal structure and function
  • participate in signaling by GPI-anchored plasma membrane proteins and in regulation of the actin cytoskeleton reorganizations, and actin-dependent cell adhesion and motility
  • with FLOT2 co-assemble into plasma membrane microdomains that are involved in the endocytosis of molecules such as glycosyl phosphatidylinositol (GPI)-linked proteins, regulated by FYN kinase
  • has a role in the nonpermissive environment that blocks locomotor recovery after spinal cord injury (SCI) by clustering unfavorable proteins in membrane rafts
  • FLOT1, FLOT2-dependent endocytosis is unlikely to be a major pathway in the syncytiotrophoblast (ST), but may be important in the cytotrophoblasts (CTs) and endothelium
  • implicated in several signaling pathways in tumor cells
  • function of FLOT2 in sorting and recycling occurs in association with RAB11A and SNX4
  • is a regulator of the RAB11A/SNX4-controlled sorting and recycling pathway, which is, like reggies, evolutionarily conserved
  • functional role for flotillins, especially FLOT2, in cell-cell adhesion in non-malignant epithelial cells
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text epidermal differentiation; formation of filopodia
    PATHWAY
    metabolism
    signaling
    a component
  • component of caveolae
  • organized as homo- and hetero-tetramers participate in signaling by GPI-anchored plasma membrane proteins and in regulation of the actin cytoskeleton reorganizations, and actin-dependent cell adhesion and motility participate in signaling by GPI-anchored plasma membrane proteins and in regulation of the actin cytoskeleton reorganizations, and actin-dependent cell adhesion and motility
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CAV1, CAV2 (stabilizes caveolin-1 in living cells and therefore my regulate caveolin-1 functions)
  • interacting with FLOT1 (required for stabilization of flotillin-1)
  • major hydrophobic protein on biomembrane microdomain lipid rafts, that is a direct transcriptional target of the TP53 family member genes
  • signaling mediator between intracellular vesicles and the cell periphery, and an interactor of the KIF9 C-terminus
  • functional role of FLOT1, FLOT2 in NPC1L1-mediated cholesterol uptake, elucidating the formation of NPC1L1-FLOT1, FLOT2-positive cholesterol-enriched membrane microdomains as a mechanism for efficient cholesterol absorption
  • by promoting EGFR internalization, FLOT1, FLOT2 restrict the EGFR signaling involved in CDH1 macropinocytosis and recycling and regulate adherens junctions (AJs) formation and dynamics and thereby cell adhesion
  • directly interacts with RAB11A and SNX4
    • cell & other
    REGULATION
    Other cycling of FLOT2 negatively correlated with cell-cell contact formation but stimulated by serum, epidermal growth factor and by cholesterol loading mediated by low density lipoproteins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with melanoma progression
    tumoral     --over  
    in breast cancer cell lines and tissue samples compared with normal cells and adjacent noncancerous breast tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • FLOT2 could be used as a prognostic biomarker for breast cancer progression
    • Therapy target
    ANIMAL & CELL MODELS