SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic,vesicle
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text
| resident integral membrane protein of caveolae from epithelial surface |
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associated with membrane rafts  |
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localized in microdomains different from caveolae, and the function of reggies is different from and independent of caveolin-1  |
basic FUNCTION
| involved in cell adhesion |
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may act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles |
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binds to MARK2, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may thereby influence tumor progression  |
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defining structural components of the machinery that mediates a clathrin-independent endocytic pathway  |
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may be involved in epidermal cell adhesion and epidermal structure and function |
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participate in signaling by GPI-anchored plasma membrane proteins and in regulation of the actin cytoskeleton reorganizations, and actin-dependent cell adhesion and motility  |
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with FLOT2 co-assemble into plasma membrane microdomains that are involved in the endocytosis of molecules such as glycosyl phosphatidylinositol (GPI)-linked proteins, regulated by FYN kinase  |
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has a role in the nonpermissive environment that blocks locomotor recovery after spinal cord injury (SCI) by clustering unfavorable proteins in membrane rafts  |
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FLOT1, FLOT2-dependent endocytosis is unlikely to be a major pathway in the syncytiotrophoblast (ST), but may be important in the cytotrophoblasts (CTs) and endothelium  |
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implicated in several signaling pathways in tumor cells  |
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function of FLOT2 in sorting and recycling occurs in association with RAB11A and SNX4  |
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is a regulator of the RAB11A/SNX4-controlled sorting and recycling pathway, which is, like reggies, evolutionarily conserved  |
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functional role for flotillins, especially FLOT2, in cell-cell adhesion in non-malignant epithelial cells  |