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FLASH GENE
Symbol FLOT2 contributors: mct - updated : 21-11-2014
HGNC name flotillin 2
HGNC id 3758
Location 17q11.2      Physical location : 27.206.357 - 27.224.715
Synonym name
  • membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)
  • flotillin 2, distinct from the ECS-1 antigen ESA
  • epidermal surface antigen
  • reggie-1
  • Synonym symbol(s) ECS1, REGGIE1, ESA, ESA1, M17S1
    DNA
    TYPE functioning gene
    STRUCTURE 18.36 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - FLOT2 - NF1 NF1 - qter
    Physical map
    LOC90410 17q11.2 intraflagellar transport protein IFT20 TNFAIP1 17q11 tumor necrosis factor, alpha-induced protein 1 (endothelial) PDIP38 MGC45714 17q11.2 hypothetical protein MGC45714 VTN 17q11.2 vitronectin (serum spreading factor, somatomedin B, complement S-protein) SARM1 17q11 sterile alpha and TIR motif containing 1 MGC9564 17q11.2 similar to RIKEN cDNA 1110002C08 gene LOC388363 17 similar to 40S ribosomal protein S7 (S8) SLC13A2 17p11.1-q11.1 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 FOXN1 17q11.2 forkhead box N1 UNC119 17q11.2 unc-119 homolog (C. elegans) PIGS 17p13.2 phosphatidylinositol glycan, class S ALDOC 17q11.2 aldolase C, fructose-bisphosphate SPAG5 17q11.1 sperm associated antigen 5 FLJ25006 17q11.2 hypothetical protein FLJ25006 KIAA0100 17q11.2 KIAA0100 gene product SDF2 17q11.2 stromal cell-derived factor 2 SUPT6H 17q11.2 suppressor of Ty 6 homolog (S. cerevisiae) MGC39650 17q11.2 hypothetical protein MGC39650 RAB34 17q11.1 RAB34, member RAS oncogene family RPL23A 17q11 ribosomal protein L23a LOC116238 17q11.2 hypothetical protein BC014072 NEK8 17q11.1 NIMA (never in mitosis gene a)- related kinase 8 TRAF4 17q11-q12 TNF receptor-associated factor 4 FLJ10700 17q11.2 hypothetical protein FLJ10700 ERAL1 17q11.2 Era G-protein-like 1 (E. coli) FLOT2 17q11.2-q12 flotillin 2 MGC23280 17q11.2 hypothetical protein MGC23280 PHF12 17q11.2 PHD finger protein 12 SEZ6 17q11.2 seizure related 6 homolog (mouse) LOC342659 17q11.2 similar to NADH-ubiquinone oxidoreductase 15 kDa subunit (Complex I-15 kDa) (CI-15 kDa) PIPOX 17q11.2 pipecolic acid oxidase TIAF1 17q11.1-q11.2 TGFB1-induced anti-apoptotic factor 1 LOC390783 17 hypothetical gene supported by U02680; NM_002822 CRYBA1 17q11.2-q12 crystallin, beta A1 182-FIP 17q11.2 82-kD FMRP Interacting Protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2659 47 428 - 2007 17482312
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • integral membrane protein with a Epb72 domain
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • EPB72/stomatin family
  • band 7/mec-2 family
  • flotillin subfamily
  • CATEGORY chaperone/stress , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • resident integral membrane protein of caveolae from epithelial surface
  • associated with membrane rafts
  • localized in microdomains different from caveolae, and the function of reggies is different from and independent of caveolin-1
  • basic FUNCTION
  • involved in cell adhesion
  • may act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles
  • binds to MARK2, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may thereby influence tumor progression
  • defining structural components of the machinery that mediates a clathrin-independent endocytic pathway
  • may be involved in epidermal cell adhesion and epidermal structure and function
  • participate in signaling by GPI-anchored plasma membrane proteins and in regulation of the actin cytoskeleton reorganizations, and actin-dependent cell adhesion and motility
  • with FLOT2 co-assemble into plasma membrane microdomains that are involved in the endocytosis of molecules such as glycosyl phosphatidylinositol (GPI)-linked proteins, regulated by FYN kinase
  • has a role in the nonpermissive environment that blocks locomotor recovery after spinal cord injury (SCI) by clustering unfavorable proteins in membrane rafts
  • FLOT1, FLOT2-dependent endocytosis is unlikely to be a major pathway in the syncytiotrophoblast (ST), but may be important in the cytotrophoblasts (CTs) and endothelium
  • implicated in several signaling pathways in tumor cells
  • function of FLOT2 in sorting and recycling occurs in association with RAB11A and SNX4
  • is a regulator of the RAB11A/SNX4-controlled sorting and recycling pathway, which is, like reggies, evolutionarily conserved
  • functional role for flotillins, especially FLOT2, in cell-cell adhesion in non-malignant epithelial cells
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text epidermal differentiation; formation of filopodia
    PATHWAY
    metabolism
    signaling
    a component
  • component of caveolae
  • organized as homo- and hetero-tetramers participate in signaling by GPI-anchored plasma membrane proteins and in regulation of the actin cytoskeleton reorganizations, and actin-dependent cell adhesion and motility participate in signaling by GPI-anchored plasma membrane proteins and in regulation of the actin cytoskeleton reorganizations, and actin-dependent cell adhesion and motility
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CAV1, CAV2 (stabilizes caveolin-1 in living cells and therefore my regulate caveolin-1 functions)
  • interacting with FLOT1 (required for stabilization of flotillin-1)
  • major hydrophobic protein on biomembrane microdomain lipid rafts, that is a direct transcriptional target of the TP53 family member genes
  • signaling mediator between intracellular vesicles and the cell periphery, and an interactor of the KIF9 C-terminus
  • functional role of FLOT1, FLOT2 in NPC1L1-mediated cholesterol uptake, elucidating the formation of NPC1L1-FLOT1, FLOT2-positive cholesterol-enriched membrane microdomains as a mechanism for efficient cholesterol absorption
  • by promoting EGFR internalization, FLOT1, FLOT2 restrict the EGFR signaling involved in CDH1 macropinocytosis and recycling and regulate adherens junctions (AJs) formation and dynamics and thereby cell adhesion
  • directly interacts with RAB11A and SNX4
  • cell & other
    REGULATION
    Other cycling of FLOT2 negatively correlated with cell-cell contact formation but stimulated by serum, epidermal growth factor and by cholesterol loading mediated by low density lipoproteins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with melanoma progression
    tumoral     --over  
    in breast cancer cell lines and tissue samples compared with normal cells and adjacent noncancerous breast tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • FLOT2 could be used as a prognostic biomarker for breast cancer progression
  • Therapy target
    ANIMAL & CELL MODELS