| basic FUNCTION
| formation of filopodia |
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playing a role in formation of caveolae or caveolae-like vesicles and in cholesterol enriched microdomains (lipid rafts) formation |
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defining structural components of the machinery that mediates a clathrin-independent endocytic pathway |
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STX12, FLOT1, and ABCA1 were identified as phagosomal proteins, indicating the involvement of the phagosomal compartment in ABCA1-mediated lipid efflux  |
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defining structural components of the machinery that mediates a clathrin-independent endocytic pathway |
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regulates caveolin-1 level by preventing its lysosomal degradation in intestinal epithelial cells |
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participate in signaling by GPI-anchored plasma membrane proteins and in regulation of the actin cytoskeleton reorganizations, and actin-dependent cell adhesion and motility |
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with FLOT2 co-assemble into plasma membrane microdomains that are involved in the endocytosis of molecules such as glycosyl phosphatidylinositol (GPI)-linked proteins, regulated by FYN kinase |
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FLOT1 signaling pathway for hippocampal neurite branching is regulated by LRFN3 |
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a critical role of Flot1-enriched membrane microdomains in protein kinase C-triggered DAT endocytosis and the actions of amphetamine ( |
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plays a direct role during both the early phase and late phase of growth factor signaling |
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a scaffolding factor in the regulation of classical MAP kinase signaling |
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FLOT1, FLOT2-dependent endocytosis is unlikely to be a major pathway in the syncytiotrophoblast (ST), but may be important in the cytotrophoblasts (CTs) and endothelium |
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functional role for flotillins, especially FLOT2, in cell-cell adhesion in non-malignant epithelial cells |
