Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
Symbol FLOT1 contributors: mct/shn - updated : 10-05-2013
HGNC name flotillin 1
HGNC id 3757
Location 6p21.33      Physical location : 1.988.444 - 30.710.453
Synonym name
  • resident integral membrane protein of caveolae from epithelial surface
  • antigen identified by monoclonal antibody ECS-1
  • integral membrane component of caveolae
  • reggie-2
  • Synonym symbol(s) ESA, FLT1, REGGIE2
    TYPE functioning gene
    STRUCTURE 14.94 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D6S1022 - D6S1624 -FLOT1 - D6S1615 - D6S1014 - cen
    Physical map
    TRIM39 6p21.3 tripartite motif-containing 39 C6orf135 6p21.32 chromosome 6 open reading frame 135 MICC 6p21.3 MHC class I polypeptide-related sequence C LOC346173 6p21.32 similar to Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial precursor (Succinyl-CoA synthetase, betaA chain) (SCS-betaA) (ATP-specific succinyl-CoA synthetase beta subunit) RANP1 6p21.32 RAN, member RAS oncogene family pseudogene 1 HLA-E 6p21.3 major histocompatibility complex, class I, E GNL1 6p21.3 guanine nucleotide binding protein-like 1 PRR3 6p21.32 proline-rich polypeptide 3 ABCF1 6p21.33 ATP-binding cassette, sub-family F (GCN20), member 1 PPP1R10 6p21.3 protein phosphatase 1, regulatory subunit 10 MRPS18B 6p21.3 mitochondrial ribosomal protein S18B C6orf134 6p21.32 chromosome 6 open reading frame 134 C6orf136 6p21.32 chromosome 6 open reading frame 136 DHX16 6p21.3 DEAH (Asp-Glu-Ala-His) box polypeptide 16 KIAA1949 6p21.3 KIAA1949 protein NRM 6p21.31 nurim (nuclear envelope membrane protein) MDC1 6pter-p21.3 mediator of DNA damage checkpoint 1 OK/SW-cl.56 6p21.32 beta 5-tubulin FLOT1 6p21.3 flotillin 1 IER3 6p21.3 immediate early response 3 DDR1 6p21.3 discoidin domain receptor family, member 1 VARS2L 6p21.33 valyl-tRNA synthetase 2-like GTF2H4 6p21.3 general transcription factor IIH, polypeptide 4, 52kDa LOC389376 6 similar to GSGL541 DPCR1 6p21.32 similar to GSGL541 LOC389377 6 similar to KMQK697 C6orf15 6p21.3 chromosome 6 open reading frame 15 PSORS1C1 6p21.3 psoriasis susceptibility 1 candidate 1 CDSN 6p21.3 corneodesmosin
    TRANSCRIPTS type messenger
    text alternative polyadenylation signals
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1839 47.2 427 - 2001 11167132
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly Homo sapiens
    cell lineage
    cell lines
    at STAGE
  • hydrophobic N terminal region
  • SPFH domain
  • long central alpha helical domain forming a coiled-coil
  • mono polymer homomer , heteromer , tetramer
    interspecies ortholog to Flot 1, Mus musculus
    ortholog to Flot 1, Rattus norvegicus
    ortholog to flot1, Danio rerio
    ortholog to FLOT1, Pan troglodytes
    intraspecies homolog to prohibitin
  • EPB72/stomatin family
  • band 7/mec-2 family
  • flotillin subfamily
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
  • membrane associated protein of caveolae
  • cholesterol enriched microdomains (lipid rafts)
  • localized in microdomains different from caveolae, and the function of reggies is different from and independent of caveolin-1
  • basic FUNCTION
  • formation of filopodia
  • playing a role in formation of caveolae or caveolae-like vesicles and in cholesterol enriched microdomains (lipid rafts) formation
  • defining structural components of the machinery that mediates a clathrin-independent endocytic pathway
  • STX12, FLOT1, and ABCA1 were identified as phagosomal proteins, indicating the involvement of the phagosomal compartment in ABCA1-mediated lipid efflux
  • defining structural components of the machinery that mediates a clathrin-independent endocytic pathway
  • regulates caveolin-1 level by preventing its lysosomal degradation in intestinal epithelial cells
  • participate in signaling by GPI-anchored plasma membrane proteins and in regulation of the actin cytoskeleton reorganizations, and actin-dependent cell adhesion and motility
  • with FLOT2 co-assemble into plasma membrane microdomains that are involved in the endocytosis of molecules such as glycosyl phosphatidylinositol (GPI)-linked proteins, regulated by FYN kinase
  • FLOT1 signaling pathway for hippocampal neurite branching is regulated by LRFN3
  • a critical role of Flot1-enriched membrane microdomains in protein kinase C-triggered DAT endocytosis and the actions of amphetamine (
  • plays a direct role during both the early phase and late phase of growth factor signaling
  • a scaffolding factor in the regulation of classical MAP kinase signaling
  • FLOT1, FLOT2-dependent endocytosis is unlikely to be a major pathway in the syncytiotrophoblast (ST), but may be important in the cytotrophoblasts (CTs) and endothelium
  • functional role for flotillins, especially FLOT2, in cell-cell adhesion in non-malignant epithelial cells
    a component
  • component of rafts/microdomains
  • forming a ternary complex with CBL and the adaptor protein CAP that could be crucial in the regulation of glucose uptake
  • organized as homo- and hetero-tetramers
    small molecule
  • PTOV1
  • adapter protein CAP and Cbl proto-oncogene (
  • Neuroglobin, Ngb (
  • Arginase (
  • caveolin 1, CAV1 and caveolin 2, CAV2
  • amyloid precursor protein, APP (
  • is a molecular mediator of neurite branching for LRFN3
  • functional role of FLOT1, FLOT2 in NPC1L1-mediated cholesterol uptake, elucidating the formation of NPC1L1-FLOT1, FLOT2-positive cholesterol-enriched membrane microdomains as a mechanism for efficient cholesterol absorption
  • EGFR, CRAF, MEK1, ERK, and KSR1
  • by promoting EGFR internalization, FLOT1, FLOT2 restrict the EGFR signaling involved in CDH1 macropinocytosis and recycling and regulate adherens junctions (AJs) formation and dynamics and thereby cell adhesion
  • cell & other
    corresponding disease(s)
    Variant & Polymorphism
    Candidate gene
    Therapy target
  • knockdown of flotillin-1/reggie-2 results in reduced EGF-induced phosphorylation of specific tyrosines in the EGF receptor and in inefficient activation of the downstream mitogen-activated protein kinase and Akt signaling