| protein
| interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and FRAP1 signaling |
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may interact with the energy- and nutrient-sensing AMPK-MTOR signaling pathways  |
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two FLCN binding proteins FNIP1 and FNIP2, interacting with AMPK, an important energy sensor in cells that negatively regulates MTOR, the master switch for cell growth and proliferation |
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PKP4 is a potential novel FLCN interacting protein |
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FLCN and PSMC6 interaction may be evolutionarily conserved between flies and humans |
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FLCN-GABARAP association is modulated by the presence of either folliculin-interacting protein FNIP1 or FNIP2 and further regulated by ULK1 |
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FNIP1 and FNIP2 play critical roles in kidney tumor suppression in cooperation with FLCN |
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important roles for FLCN, FNIP1 and FNIP2 in cell metabolism, which include AMP-activated protein kinase-mediated energy sensing, PPARGC1A-driven mitochondrial oxidative phosphorylation and MTOR-dependent cell proliferation |
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FLCN is an HSP90AA1 client protein and its binding partners FNIP1/FNIP2 function as co-chaperones |
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FLCN and FNIP2 assemble into one complex via an intricate domain arrangement, and they interact with the G domains of the Rag GTPases in their ‘inactive’ state |
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absence of FLCN or its binding partners FNIP1/FNIP2 induces interferon response genes independently of interferon |
