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FLASH GENE
Symbol FLAD1 contributors: mct - updated : 29-06-2016
HGNC name Fad1, flavin adenine dinucleotide synthetase, homolog (yeast)
HGNC id 24671
Corresponding disease
MADD2 Multiple acyl-CoA dehydrogenase deficiencies 2
Location 1q22      Physical location : 154.955.769 - 154.965.587
Genatlas name FAD-synthetase
Synonym name
  • FAD-pyrophosphorylase
  • FMN adenylyltransferase
  • Fad1, flavin adenine dinucleotide synthetase, homolog
    • Synonym symbol(s) MGC31803, MGC40255, PP591, FAD1, FADS
    EC.number 2.7.7.2
    DNA
    TYPE functioning gene
    STRUCTURE 9.82 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 2260 65 587 localized in mitochondria 2006 16643857
    8 splicing 1816 54 490 - 2006 16643857
  • lacking a segment in the 5' region compared to variant 1
  • using a downstream start codon compared to variant 1
    • 7 - 1931 - 446 - 2006 16643857
    4 - 1911 - 294 - 2006 16643857
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Reproductivefemale systemuteruscervix highly
    Urinarybladder   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a catalytic domain of flavin adenine dinucleotide synthetase, the FADS domain able to mediate FADS activity
  • a MPTb domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme
  • ubiquitous enzyme that catalyses the last step of FAD biosynthesis, allowing for the biogenesis of several flavoproteins
  • "redox sensing" enzyme acting as a "FAD chaperone"
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism cofactor , other
    signaling
  • mo-molybdopterin cofactor biosynthesis
  • amino acid biosynthesis
  • cysteine biosynthesis
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MADD2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS