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FLASH GENE
Symbol FKBPL contributors: npt/mct - updated : 24/12/2008
HGNC name FK506 binding protein like
HGNC id 13949
Location 6p21.3      Physical location : 3.375.658 - 32.098.067
Synonym name WAF-1/CIP1 stabilizing protein 39
Synonym symbol(s) DIR1, NG7, WISp39
DNA
TYPE functioning gene
STRUCTURE 1.58 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LSM2 6p21.3 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) HSPA1L 6p21.3 heat shock 70kDa protein 1-like HSPA1A 6p21.3 heat shock 70kDa protein 1A HSPA1B 6p21.3 heat shock 70kDa protein 1B C6orf48 6p21.3 chromosome 6 open reading frame 48 NEU1 6p21.3 sialidase 1 (lysosomal sialidase) C6orf29 6p21.3 chromosome 6 open reading frame 29 BAT8 6p21.31 HLA-B associated transcript 8 C6orf46 6p21.31 chromosome 6 open reading frame 46 C2 6p21.3 complement component 2 BF 6p21.3 B-factor, properdin RDBP 6p21.33 RD RNA binding protein SKIV2L 6p21.3 superkiller viralicidic activity 2-like (S. cerevisiae) DOM3Z 6p21.3 dom-3 homolog Z (C. elegans) STK19 6p21.3 serine/threonine kinase 19 C4B 6p21.3 complement component 4B CYP21A2 6p21.3 cytochrome P450, family 21, subfamily A, polypeptide 2 TNXB 6p21.3 tenascin XB CREBL1 6p21.3 cAMP responsive element binding protein-like 1 FKBPL 6p21.3 FK506 binding protein like C6orf31 6p21.1 chromosome 6 open reading frame 31 PPT2 6p21.3 palmitoyl-protein thioesterase 2 EGFL8 6p21.31 EGF-like-domain, multiple 8 AGPAT1 6p21.3 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) RNF5 6p21.31 ring finger protein 5 AGER 6p21.3 advanced glycosylation end product-specific receptor PBX2 6p21.3 pre-B-cell leukemia transcription factor 2 C6orf9 6p21.3 chromosome 6 open reading frame 9 NOTCH4 6p21.3 Notch homolog 4 (Drosophila) C6orf10 6p21.3 chromosome 6 open reading frame 10
regionally located close to TNXA,TNXB and CREBL1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1357 38 349 - Jascur (2005)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three tetratricopeptide repeat (TPR) domains
HOMOLOGY
Homologene
FAMILY
  • immunophilin class of proteins family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • stress-response related gene potentially involved in induced radio resistance
  • plays a role in the cellular stress response
  • can be classed as a new member of the FKBP protein family with a role in steroid receptor complexes and signaling
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    text control of cell cycle
    PATHWAY
    metabolism
    signaling
    a component FKBPL, CDKN1A, and HSP90AA1 form a trimeric complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein tetratricopeptide repeat (TPR) protein that binds CDKN1A (importance of posttranslational stabilization of CDKN1A protein by FKBPL in regulating cellular CDKN1A activity)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    repression of FKBPL (DIR1) gene leads to an increased in the note of repair and cell survival in radio resistant cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS