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FLASH GENE
Symbol FKBP9 contributors: mct/npt - updated : 24/12/2008
HGNC name FK506 binding protein 9, 63 kDa
HGNC id 3725
Location 7p11.1      Physical location : 32.997.004 - 33.046.542
Synonym name
  • peptidyl-prolyl cis-trans isomerase
  • rotamase
  • Synonym symbol(s) FKBP60, FKBP63, PPIase, DKFZp586B1723, MGC126772, MGC138258
    EC.number 5.2.1.8
    DNA
    TYPE functioning gene
    STRUCTURE 49.50 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DKFZp434G0625 7q32.3 hypothetical protein DKFZp434G0625 PDE1C 7p15.3 phosphodiesterase 1C, calmodulin-dependent 70kDa FLJ40288 7q32.3 hypothetical protein FLJ40288 FLJ20420 LOC392882 7 similar to PRPS2 protein LOC392883 7 similar to ADP,ATP carrier protein, fibroblast isoform (ADP/ATP translocase 2) (Adenine nucleotide translocator 2) (ANT 2) LSM5 7p14.3 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) KIAA0241 7p14.3 KIAA0241 protein LOC89231 7p14.3 LOC89231 LOC392989 7 hypothetical gene supported by AK130770; NM_003932 LOC392012 7 similar to PRPS2 protein LOC392013 7 similar to ADP,ATP carrier protein, fibroblast isoform (ADP/ATP translocase 2) (Adenine nucleotide translocator 2) (ANT 2) LSM5 7p14.3 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) KIAA0241 7p14.3 KIAA0241 protein KBTBD2 7p14.3 kelch repeat and BTB (POZ) domain containing 2 SEC8 LOC392652 7 similar to Retinitis pigmentosa 9 protein (Pim-1 associated protein) (PAP-1) FKBP9 7p11.1 FK506 binding protein 9, 63 kDa LOC89231 7p14.3 LOC89231 NT5C3 7p14.3 5'-nucleotidase, cytosolic III LOC222136 B1 7p14 parathyroid hormone-responsive B1 gene KBTBD2 7p14.3 kelch repeat and BTB (POZ) domain containing 2 LOC389477 7 similar to Retinitis pigmentosa 9 protein (Pim-1 associated protein) (PAP-1) FKBP9 7p11.1 FK506 binding protein 9, 63 kDa NT5C3 7p14.3 5'-nucleotidase, cytosolic III LOC222136 B1 7p14 parathyroid hormone-responsive B1 gene FLJ20712 7p14.3 hypothetical protein FLJ20712 FLJ32786 7q33 hypothetical protein FLJ32786 BMPER 7p14.3 hypothetical protein FLJ32786 SLC35B4 7q33 solute carrier family 35, member B4 AKR1B1 7q25 aldo-keto reductase family 1, member B1 (aldose reductase) FLJ20712 7p14.3 hypothetical protein FLJ20712 AKR1B10 7q33 aldo-keto reductase family 1, member B10 (aldose reductase) LOC392990 7 similar to aldo-keto reductase family 1, member B10; aldose reductase-like 1; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like peptide; aldose reductase-related protein; small intestine reducta BMPER 7p14.3 similar to aldo-keto reductase family 1, member B10; aldose reductase-like 1; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like peptide; aldose reductase-related protein; small intestine reducta BPGM 7q32 2,3-bisphosphoglycerate mutase LOC392991 7 similar to beta-tubulin CALD1 7q33-q34 caldesmon 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3491 63 570 - Patterson (2002)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   moderately
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple N terminal FK506 binding
  • peptidyl prolyl cis-trans isomerase (rotamase) domains
  • a C terminal tetratricopeptide repeat domain
  • EF-hand domain
  • HOMOLOGY
    interspecies homolog to murine Fkbp9
    intraspecies homolog to FKBP10
    Homologene
    FAMILY
  • peptidylprolyl isomerase family
  • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • accelerate effectively the isomerization of the peptidyl-prolyl bond
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS