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FLASH GENE
Symbol FKBP9 contributors: mct/npt - updated : 24/12/2008
HGNC name FK506 binding protein 9, 63 kDa
HGNC id 3725
Location 7p11.1      Physical location : 32.997.004 - 33.046.542
Synonym name
  • peptidyl-prolyl cis-trans isomerase
  • rotamase
    • Synonym symbol(s) FKBP60, FKBP63, PPIase, DKFZp586B1723, MGC126772, MGC138258
    EC.number 5.2.1.8
    DNA
    TYPE functioning gene
    STRUCTURE 49.50 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3491 63 570 - Patterson (2002)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   moderately
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple N terminal FK506 binding
  • peptidyl prolyl cis-trans isomerase (rotamase) domains
  • a C terminal tetratricopeptide repeat domain
  • EF-hand domain
    • HOMOLOGY
    interspecies homolog to murine Fkbp9
    intraspecies homolog to FKBP10
    Homologene
    FAMILY
  • peptidylprolyl isomerase family
    • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • accelerate effectively the isomerization of the peptidyl-prolyl bond
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS