basic FUNCTION
| T cell binding protein FKBP for the immunosuppressive agents FK506-rapamycin, but lacking immuno suppressant activity |
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playing a role in regulating tissue-specific hormone action and in uterine receptivity for implantation |
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component of the copper efflux machinery, and in so, may also promote neuroprotection from copper toxicity |
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tetratricopeptide repeat (TPR)-containing cochaperone that influences steroid hormone receptor function |
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has an important physiological role in up-regulating androgen receptor activity, an essential step in the development of the male external genitalia |
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likely to play a role in growth and development of the male genitalia, since it is expressed in the genital skin of prepubertal boys |
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serves as a cochaperone to govern normal progesterone receptor (PR) function |
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playing a role in modulating toxicity of Abeta peptides in Alzheimer disease |
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playing a role in MAPT function and may help to decipher and modulate the events involved in MAPT-induced neurodegeneration |
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interacts with MAPT, inhibits its ability to promote microtubule assembly and can have a role in MAPT function |
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immunophilin with neuroprotective effects on different kinds of neurons |
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functional role of RET51/FKBP4 complex in dopaminergic neurons and possibly in the pathogenesis of Parkinson disease |
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regulates oxidative stress (OS) by regulating the levels of a unique antioxidant, peroxiredoxin-6 (PRDX6), which operates independently of other peroxiredoxins and antioxidant proteins |
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important molecular regulator in the androgen-mediated pathway of urethra morphogenesis,and in hypospadias development |
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essential to AR-mediated induction of genes involved in sexually dimorphic development of the penis (NKX3-1), in erectile function of the mature organ (NOS2 and NOS3), and in promotion of apoptosis during development |
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CDK5R1, HOPX, FKBP4, SGTA proteins plays a distinct role in the steroid hormone receptor regulatory cycle |