SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,nucleus,chromatin/chromosome,nucleosome
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text
| endogenous FKBP3 is associated to the core histones of the nucleosome, and with several proteins forming spliceosomal complexes and ribosomal subunits  |
basic FUNCTION
| T cell binding protein FKBP-25 for the immunosuppressive agents FK506-rapamycin |
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intrinsic peptidyl-prolyl cis-trans isomerase activity |
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contributes to regulation of the TP53-MDM2 negative feedback loop  |
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DNA-binding protein that encompasses peptidylprolyl cis–trans isomerase (PPI) activity  |
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can stimulate the ability of MDM2 to undergo auto-ubiquitylation leading to its rapid degradation  |
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plays an important role in regulating transcription and chromatin structure  |
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catalyze the cis-trans isomerization of prolyl-peptide bonds in proteins  |
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nuclear protein that has been shown to associate with chromatin modifiers and transcription factors  |
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is likely recruited to preribosomes to chaperone one of the protein components of the ribosome large subunit  |
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evidence for a role of immunophilins, including FKBP3 and FKBP8, in Non-capacitative calcium entry (NCCE) mediated by TRPC6  |