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FLASH GENE

Symbol

FKBP3

contributors: npt/mct - updated : 20-04-2017

HGNC name	FK506 binding protein 3, 25kDa
HGNC id	3719

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q21.2      Physical location : 45.584.802 - 45.603.732
Synonym name	rotamase
	rapamycin-selective 25 kDa immunophilin
	FK506-binding protein 25, T-cell
	peptidyl-prolyl cis-trans isomerase
Synonym symbol(s)	FKBP25, PPIase, FK506
EC.number	5.2.1.8

DNA

TYPE	functioning gene
STRUCTURE	18.93 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

inconsistent : contradictory evidence

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002013 8 - 1353 NP_002004 25 224 - Ochocka (2009)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus         Hearing/Equilibrium ear       highly Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly Lymphoid         Muscular striatum skeletal   highly

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal FK506 binding and peptidyl prolyl cis-trans isomerase (rotamase) domain
	three tetratricopeptide repeat (TPR) motifs consistent nuclear transcript or chaperone activity
	C-terminal FK506-binding domain (FKBD)

HOMOLOGY

Homologene

FAMILY	immunophilin class of proteins family
	FKBP-type PPIase family
	super-family of peptidylprolyl cis/trans isomerases

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus,chromatin/chromosome,nucleosome
text	endogenous FKBP3 is associated to the core histones of the nucleosome, and with several proteins forming spliceosomal complexes and ribosomal subunits

basic FUNCTION	T cell binding protein FKBP-25 for the immunosuppressive agents FK506-rapamycin
	intrinsic peptidyl-prolyl cis-trans isomerase activity
	contributes to regulation of the TP53-MDM2 negative feedback loop
	DNA-binding protein that encompasses peptidylprolyl cis–trans isomerase (PPI) activity
	can stimulate the ability of MDM2 to undergo auto-ubiquitylation leading to its rapid degradation
	plays an important role in regulating transcription and chromatin structure
	catalyze the cis-trans isomerization of prolyl-peptide bonds in proteins
	nuclear protein that has been shown to associate with chromatin modifiers and transcription factors
	is likely recruited to preribosomes to chaperone one of the protein components of the ribosome large subunit
	evidence for a role of immunophilins, including FKBP3 and FKBP8, in Non-capacitative calcium entry (NCCE) mediated by TRPC6

CELLULAR PROCESS

protein, post translation, folding

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

	cellular trafficking
	ESD/FKBP3/MTOR signaling pathway is involved in inhibiting tumor cell growth via regulating autophagy

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with MDM2 (stimulates auto-ubiquitylation and proteasomal degradation of MDM2, leading to the induction of TP53)
	both TREM2 and OSCAR were inhibited by FKBP3 in the late stage of osteoclast formation
	interacts with chromatin-related proteins and transcription factors and is suggested to interact with nucleic acids

cell & other

REGULATION

inhibited by

predominantly by rapamycin

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS