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FLASH GENE
Symbol FKBP3 contributors: npt/mct - updated : 20-04-2017
HGNC name FK506 binding protein 3, 25kDa
HGNC id 3719
Location 14q21.2      Physical location : 45.584.802 - 45.603.732
Synonym name
  • rotamase
  • rapamycin-selective 25 kDa immunophilin
  • FK506-binding protein 25, T-cell
  • peptidyl-prolyl cis-trans isomerase
    • Synonym symbol(s) FKBP25, PPIase, FK506
    EC.number 5.2.1.8
    DNA
    TYPE functioning gene
    STRUCTURE 18.93 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status inconsistent : contradictory evidence
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1353 25 224 - Ochocka (2009)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Hearing/Equilibriumear   highly
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Lymphoid    
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal FK506 binding and peptidyl prolyl cis-trans isomerase (rotamase) domain
  • three tetratricopeptide repeat (TPR) motifs consistent nuclear transcript or chaperone activity
  • C-terminal FK506-binding domain (FKBD)
    • HOMOLOGY
    Homologene
    FAMILY
  • immunophilin class of proteins family
  • FKBP-type PPIase family
  • super-family of peptidylprolyl cis/trans isomerases
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text
  • endogenous FKBP3 is associated to the core histones of the nucleosome, and with several proteins forming spliceosomal complexes and ribosomal subunits
    • basic FUNCTION
  • T cell binding protein FKBP-25 for the immunosuppressive agents FK506-rapamycin
  • intrinsic peptidyl-prolyl cis-trans isomerase activity
  • contributes to regulation of the TP53-MDM2 negative feedback loop
  • DNA-binding protein that encompasses peptidylprolyl cis–trans isomerase (PPI) activity
  • can stimulate the ability of MDM2 to undergo auto-ubiquitylation leading to its rapid degradation
  • plays an important role in regulating transcription and chromatin structure
  • catalyze the cis-trans isomerization of prolyl-peptide bonds in proteins
  • nuclear protein that has been shown to associate with chromatin modifiers and transcription factors
  • is likely recruited to preribosomes to chaperone one of the protein components of the ribosome large subunit
  • evidence for a role of immunophilins, including FKBP3 and FKBP8, in Non-capacitative calcium entry (NCCE) mediated by TRPC6
    • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    cellular trafficking
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MDM2 (stimulates auto-ubiquitylation and proteasomal degradation of MDM2, leading to the induction of TP53)
  • both TREM2 and OSCAR were inhibited by FKBP3 in the late stage of osteoclast formation
  • interacts with chromatin-related proteins and transcription factors and is suggested to interact with nucleic acids
    • cell & other
    REGULATION
    inhibited by predominantly by rapamycin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS