protein
| modulating RYR1, RYR2 and RYR3 |
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physically interacts and stabilizes RYR1 by decreasing channel open probability, playing the role for endogenous RYR stabilizer |
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binds to the glycine- and serine-rich motif (GS motif) of the TGF-beta type I receptor, and functions as a secure switch to prevent the leaky signal |
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bind to the skeletal muscle sarcoplasmic reticulum Ca2+ release channel [ryanodine receptor (RYR1)] and plays an important role in excitation-contraction coupling |
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interacted with another inhibitory molecule of activin signal, SMAD7, in an activin-dependent manner, and formed a complex with SMAD7 on the type I receptor |
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binds to HRAS in a palmitoylation-dependent fashion and promotes depalmitoylation |
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functionally interacts with EGFR (inhibit EGF-induced EGFR autophosphorylation with all internal phosphorylation sites equally affected) |
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interaction between FKBP1A and RYR1, RYR3 and ITPR1 |
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promotes the RYR1 closed state, thereby inhibiting Ca2+ leakage in resting muscle |
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FKBP1A preferentially targets the BMP receptor ACVR1 |