SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,peroxisome
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text
| anchored at the outer membrane by a C-terminal transmembrane domain |
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MFF and FIS1 are both tail anchored in the mitochondrial outer membrane |
basic FUNCTION
| may regulates mitochondrial fission and perinuclear clustering by interacting with DNM1L |
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anchors fission complexes onto the mitochondrial outer membrane |
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fragmentation followed by the release of cytochrome c and apoptosis, suggesting that regulation of the fission may be involved in apoptotic mechanisms |
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limiting factor in mitochondrial fission, the number of FIS1 molecules on the mitochondrial surface determines fission frequency |
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mediating peroxisomal fission |
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DNM1L, and FIS1 are two key players of mitochondrial fission |
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oligomerization of FIS1 in the mitochondrial outer membrane plays a role in mitochondrial fission, potentially through participating in fission factor recruitment |
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