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FLASH GENE
Symbol FIP1L1 contributors: - updated : 09-02-2006
HGNC name FIP1 like 1 (S. cerevisiae)
HGNC id 19124
Location 4q11-q12      Physical location : 54.243.819 - 54.326.102
Synonym name
  • factor interacting with PAP
  • rearranged in hypereosinophilia
  • integral subunit of CPSF1
    • Synonym symbol(s) DKFZp586K0717, Rhe, FLJ33619
    DNA
    TYPE functioning gene
    STRUCTURE 83.00 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA0276 4q12 LOC391654 LOC339977 4q12 similar to Hypothetical protein MGC38937 SGCB 4q12 sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) LOC132671 4q12 LOC132671 USP46 4q12 ubiquitin specific protease 46 KIAA0114 4q12 KIAA0114 gene product FLJ12684 4q12 hypothetical protein FLJ12684 MGC2827 4q12 hypothetical protein MGC2827 STXBP1L1 FIP1L1 4q11-q12 FIP1 like 1 (S. cerevisiae) LNX 4q12 ligand of numb-protein X LOC391653 4 hypothetical gene supported by BC057822 CHIC2 4q11-q12 cysteine-rich hydrophobic domain 2 GSH-2 4q11-q12 homeobox protein GSH-2 PDGFRA 4q11-q12 platelet-derived growth factor receptor, alpha polypeptide LOC254938 4q12 hypothetical LOC254938 KIT 4q12 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog KDR 4q12 kinase insert domain receptor (a type III receptor tyrosine kinase) FLJ13352 4q12 hypothetical protein FLJ13352 TPARL 4q12 TPA regulated locus CLOCK 4q12 clock homolog (mouse) GCPHLP 4q12 likely ortholog of mouse germ cell-specific phosphoducin-like protein Mgcphlp NMU 4q12 neuromedin U SEC3 FLJ13621 4q12 hypothetical protein FLJ13621 KIAA0635 4q12-q13.3 hypothetical protein FLJ13621 KIAA1211 4q12 KIAA1211 protein MRPL22P1 4q12 KIAA1211 protein NRPS998 4q12 2-aminoadipic 6-semialdehyde dehydrogenase PPAT 4q12 phosphoribosyl pyrophosphate amidotransferase PAICS 4q12 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase SRP72 1q32 signal recognition particle 72kDa LOC132946 4q12 similar to MGC69138 protein LOC391654 4 LOC391654
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Lymphoid/Immunethymus    
    Reproductivefemale systemuterus   
     female systemovary   
     male systemtestis   
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		Fip1 motif
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Fip1l1
    ortholog to rattus Fip1l1_predicted
    Homologene
    FAMILY FIP1 family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • contributing to CPSF1-mediated stimulation of poly(A) polymerase (PAP)activity
    • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the polyadenylation factor 1 complex
    INTERACTION
    DNA
    RNA binds to U-rich RNA elements and stimulates poly(A) polymerase
    small molecule
    protein
  • interacting with poly(A) polymerase (PAP) and having an arginine-rich RNA-binding motif that preferentially binds to U-rich sequence elements on the pre-mRNA
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion deletion --other protein chimeric
    acquired 4q12 deletion resulting in FIP1L1/PDGFRA fusion gene in about halfof the cases of idiopathic hypereosinophilic syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS