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FLASH GENE

Symbol

FIP1L1

contributors: mct - updated : 23-03-2020

HGNC name	factor interacting with PAPOLA and CPSF1
HGNC id	19124

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4q12      Physical location : 54.243.819 - 54.326.102
Synonym name	factor interacting with PAP
	rearranged in hypereosinophilia
	integral subunit of CPSF1
	FIP1-like 1 protein
	FIP1L1 cleavage and polyadenylation specific factor subunit
Synonym symbol(s)	DKFZp586K0717, Rhe, FLJ33619, FIP1, hFip1

DNA

TYPE	functioning gene
STRUCTURE	84.94 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_030917 18 - 3396 NP_112179 - 594 - 2018 29310833

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue       Lymphoid/Immune thymus         Reproductive female system uterus         female system ovary         male system testis       Respiratory respiratory tract larynx     highly

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

Fip1 motif

mono polymer

complex

HOMOLOGY

interspecies	ortholog to murine Fip1l1
	ortholog to rattus Fip1l1_predicted

Homologene

FAMILY

FIP1 family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm

basic FUNCTION

contributing to CPSF1-mediated stimulation of poly(A) polymerase (PAP)activity

CELLULAR PROCESS

nucleotide

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the polyadenylation factor 1 complex
	FIP1L1 differentially contributes to the pathogenesis of distinct types of leukemia
	a core CPSF complex comprising CPSF1, WDR33, CPSF4 and FIP1L1 is sufficient for AAUAAA motif recognition, necessary for 3' polyadenylation, a key step in eukaryotic mRNA biogenesis

INTERACTION

DNA

RNA	binds to U-rich RNA elements and stimulates poly(A) polymerase

small molecule

protein	interacting with poly(A) polymerase (PAP) and having an arginine-rich RNA-binding motif that preferentially binds to U-rich sequence elements on the pre-mRNA
	JAK2 is a mediator of FIP1L1-PDGFRA-induced eosinophil growth and function in chronic eosinophilic leukemia (CEL)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion deletion --other protein chimeric acquired 4q12 deletion resulting in FIP1L1/PDGFRA fusion gene in about half of the cases of idiopathic hypereosinophilic syndrome tumoral fusion       FIP1L1-RARA plays a pivotal role in its homodimerization and transcriptional repressor activity, contributingto the pathogenesis of distinct types of leukemia

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS