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FLASH GENE
Symbol FILIP1 contributors: mct - updated : 18-01-2014
HGNC name filamin A interacting protein 1
HGNC id 21015
Location 6q14.1      Physical location : 76.017.801 - 76.203.496
Synonym name ovarian cancer downregulated myosin heavy chain homolog
Synonym symbol(s) FILIP, KIAA1275, L-FILIP
DNA
TYPE functioning gene
STRUCTURE 198.91 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC340168 6q14.1 similar to developmental pluripotency associated 5; embryonal stem cell specific gene 1 LOC154288 6q14.1 similar to RIKEN cDNA 2410004A20 RPL39P3 6q14.1 ribosomal protein L39 pseudogene 3 DDX43 6q12-q13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 C6orf150 6q13 chromosome 6 open reading frame 150 MTO1 6q14.1 mitochondrial translation optimization 1 homolog (S. cerevisiae) EEF1A1 6q14 eukaryotic translation elongation factor 1 alpha 1 LOC389411 6 LOC389411 SLC17A5 6q14-q15 solute carrier family 17 (anion/sugar transporter), member 5 CD109 6q14.1 CD109 antigen (Gov platelet alloantigens) COL12A1 6q12-q13 collagen, type XII, alpha 1 COX7A2 6q12 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) C6orf67 6q14.1 chromosome 6 open reading frame 67 FILIP1 6q14.1 filamin A interacting protein 1 SUSP1 6q13-q14.3 filamin A interacting protein 1 MYO6 6q13 myosin VI IMPG1 6q14.2-q15 interphotoreceptor matrix proteoglycan 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 4629 138 1213 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Nervousbraindiencephalonamygdala lowly
 brainbasal nucleicaudate nucleus  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • FILIP1 family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • functioning through an FLNA-F-actin axis to initiate neocortical cell migration from the ventricular zone
  • acts through a Filamin A-F-actin axis to control the start of neocortical cell migration from the ventricular zone
  • is responsible, at least in part, for the Filamin A content of migrating neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FILIP1 interacts with Filamin A, an indispensable actin-binding protein for cell motility, and induces its degradation
  • MKRN1 is involved in carcinogenesis of the well-differentiated type of tumors possibly via ubiquitination of FILIP1
  • RHOD binds WHAMM, as well as the related filamin A-binding protein FILIP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS