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FLASH GENE
Symbol FIGLA contributors: mct/ - updated : 25-03-2021
HGNC name folliculogenesis specific basic helix-loop-helix
HGNC id 24669
Corresponding disease
POF6 premature ovarian failure, 6
Location 2p13.3      Physical location : 71.004.441 - 71.017.775
Synonym name
  • factor in the germline alpha
  • transcription factor FIGa
  • class C basic helix-loop-helix protein 8
    • Synonym symbol(s) FIGalpha, bHLHc8, POF6
    DNA
    TYPE functioning gene
    STRUCTURE 13.33 kb     5 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure
  • dynamic DNA CpG methylation in the SOHLH2 and FIGLA promoters, but not in the intron and exon sequences, is linked to the regulation of gene expressions, even though CpG islands are also present in their introns or exons
  • TAF4B occupies the proximal promoters of many essential meiosis and oogenesis regulators, including STRA8, DAZL, FIGLA, and NOBOX, and is required for their proper expression
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 722 24.1 219 - 2008 18499083
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text ovary only
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcription factor essential for oocytes to survive and form primordial follicles
  • involved in continued oocyte survival as primordial follicles
  • its physiological expression plays a critical dual role in activation of oocyte-associated genes and repression of sperm-associated genes during normal postnatal oogenesis
  • regulating expression of zona pellucida genes as well as that of other oocytes-specific genes
  • represses genes that are expressed normally in the testis
  • bHLH transcription factor, sustaining the female phenotype by activating female and repressing male germ cell genetic hierarchies in growing oocytes during postnatal ovarian development
  • FIGLA, LHX8, NOBOX, SOHLH1, and SOHLH2 transcriptional regulators are critical for formation and maintenance of follicles
  • major role for FIGLA, LHX8 and SOHLH1 as multifunctional regulators of networks necessary for oocyte maintenance and differentiation during early folliculogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with TCF3
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) POF6
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    haploinsufficiency causes premature ovarian failure by disrupting formation of primordial follcules
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS