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FLASH GENE
Symbol FGL2 contributors: SGE/npt - updated : 06-07-2010
HGNC name fibrinogen-like 2
HGNC id 3696
Location 7q11.23      Physical location : 76.822.688 - 76.829.150
Synonym name
  • fibrinogen-like protein 2
  • fibroleukin
    • Synonym symbol(s) T49, pT49
    DNA
    TYPE functioning gene
    STRUCTURE 6.46 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - D7S669 - FGL2 - D7S634 - qter
    Authors Gene Map (98)
    Physical map
    CCL26 7q11.23 chemokine (C-C motif) ligand 26 CCL24 7q11.23 chemokine (C-C motif) ligand 24 LOC392059 7 similar to ALY NPD007 7q11.23 NPD007 protein POR 7q11.2 P450 (cytochrome) oxidoreductase TMPIT 7q11.23 transmembrane protein induced by tumor necrosis factor alpha MK-STYX 7q11.23 map kinase phosphatase-like protein MK-STYX MDH2 7cen-q22 malate dehydrogenase 2, NAD (mitochondrial) LOC389525 7 similar to hypothetical protein LOC285908 LOC392060 7 similar to GrpE protein homolog 1, mitochondrial precursor (Mt-GrpE#1) (HMGE) LOC392061 7 similar to GTF2I repeat domain containing 1 isoform 2; Williams-Beuren syndrome chromosome region 11; GTF2I repeat domain-containing 1; general transcription factor 3; muscle TFII-I repeat domain-containing protein 1 alpha 1 FLJ37078 7q11.23 hypothetical protein FLJ37078 HSPB1 7q11.23 heat shock 27kDa protein 1 YWHAG 7q11.23 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide LOC392062 7 similar to peptidylprolyl isomerase A SRCRB4D 7p12.3 scavenger receptor cysteine rich domain containing, group B (4 domains) ZP3 7q11.23 zona pellucida glycoprotein 3 (sperm receptor) DTX2 7p12.3 deltex homolog 2 (Drosophila) UPK3B 7q11.2 uroplakin 3B POMZP3 7q11.23 POM (POM121 homolog, rat) and ZP3 fusion LOC392063 7 similar to Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) LOC370523 7q11.23 similar to deltex 2 LOC389526 7 hypothetical gene supported by AK024602 LOC389527 7 similar to PMS4 homolog mismatch repair protein - human LOC202802 7q11.23 similar to Williams Beuren syndrome chromosome region 19 FGL2 7q11.2 fibrinogen-like 2 LOC54103 7q21.11 hypothetical protein LOC54103 LOC392064 7 similar to hypothetical protein LOC392065 7 similar to beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; Glucosaminyl (N-acetyl) transferase 1, core 2; beta-1,6-N-acetylglucosaminyltransferase PTPN12 7q11.23 protein tyrosine phosphatase, non-receptor type 12 LOC389528 7 hypothetical gene supported by AF290475; BC037783 FLJ42526 7q21.11 FLJ42526 protein C7orf35 7q21.11 chromosome 7 open reading frame 35 PHTF2 7q11.23-q21 putative homeodomain transcription factor 2 AIP1 7q11.2 putative homeodomain transcription factor 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 4268 - 439 - Ruegg (1995)
  • precursor
    		•
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide conserved Cys residues, involved in the assembly of mature fibrinogen complex
  • two alpha-helical regions permissive for coiled-coil formation
  • five N glycosylation sites
  • a C terminal fibrinogen related domain (FRED)
    • conjugated GlycoP
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine Fgl2 (78.9pc)
    homolog to rattus Fgl2 (79.0pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text
  • secreted
    • basic FUNCTION
  • cleaved prothrombin in thrombin
  • role in fetal loss and liver diseases
  • may play a role in physiologic lymphocytes functions at mucosal sites
  • plays a vital role in the pathogenesis of some critical inflammatory diseases by processing immunomodulatory activity
  • plays an important role in macrophage activation in the lungs of COPD patients through MAPK pathway modulation (Liu 2010)
  • contributes to the hypercoagulability in cancer and may induce tumor angiogenesis and metastasis via cytokine induction (Su 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • tetrameric complex stabilized by interchain disulfide bonds
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by a mechanism involving IFNG and components of the IFNG signaling pathway including STAT1 and IRF1 (Hancock 2004)
    Other enhanced by hepatitis B virus proteins through c-Ets-2 dependent on MAPK signal pathways (Han 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
          --over  
  • upregulated in alveolar macrophages from peripheral lungs of chronic obstructive pulmonary disease (COPD) patients (Liu 2010)
    • Susceptibility
    Variant & Polymorphism
    Candidate gene
  • may be a candidate gene associated with susceptibility for SARS-coronavirus (Hsieh 2010)
    • Marker
    Therapy target
    ANIMAL & CELL MODELS
    Fgl2-deficient mice with normal numbers of lymphoid cells, surviving infection, indicating that Fgl2 is dispensable for IFNG-dependent protection against pathogens (Hancock 2004)