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FLASH GENE
Symbol FGFBP1 contributors: mct - updated : 07-03-2012
HGNC name fibroblast growth factor binding protein 1
HGNC id 19695
Location 4p15.32      Physical location : 15.937.194 - 15.939.971
Synonym name
  • heparin binding growth factor binding protein
  • HBP17 heparin-binding and FGF-binding protein
    • Synonym symbol(s) HBP17, FGFBP, FGF-BP
    DNA
    TYPE functioning gene
    STRUCTURE 2.78 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1219 - 234 - 2001 11148217
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines squamous cell carcinoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a heparin-binding domain (AAs 110-143)
  • C-terminal fragment of FGFBP1 (AAs 193-234) was identified as the minimum binding domain for FGF
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text secreted
    basic FUNCTION
  • protecting both FGF molecules from acid inactivation
  • inhibiting the mitogenic activity of FGF1
  • could influence cancer growth and tissue remodeling via its interaction with perlecan (HSPG2)
  • its overexpression after injury stimulates FGF activity at the wound site, thus enhancing the process of epithelial repair
  • secreted carrier proteins that release fibroblast growth factors (FGFs) from the extracellular matrix storage and thus enhance FGF activity
  • can be rate-limiting for tumor growth and serves as an angiogenic switch molecule
  • involved in the process of epithelial repair
  • can release FGFs from their local extracellular matrix storage, chaperone them to their cognate receptors, and thus modulate FGF signaling
  • play a significant role in fine-tuning the complex FGF signaling network during distinct phases of embryonic development
  • chaperone FGFs stored in the extracellular matrix to their receptor, and can thus modulate FGF signaling
  • can enhance FGF effects that are required for the healing and repair of injured tissues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • part of KLF5-FGFBP1-pERK-DUSP1 signaling axis, that may provide new therapeutic targets for invasive breast cancer
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to FGF1 or FGF2 in a reversible manner
  • binding to HSPG2
  • interacts with FGF7, FGF10, and with the recently identified FGF22
  • interacting with KLF5 (may promote breast cancer cell proliferation at least partially through directly activating the FGFBP1 mRNA transcription)
  • FGFBP1 was a direct transcriptional target of SOX12
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    after injury stimulates FGF activity at the wound site, thus enhancing the process of epithelial repair
    Susceptibility to osteoporosis
    Variant & Polymorphism other
  • sequence variation in FGFBP1 may contribute to variation in BMD, possibly influencing osteoporosis risk
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    represents an increasingly promising target molecule in anti-tumor therapy
    ANIMAL & CELL MODELS