basic FUNCTION
| regulation of proliferation and differentiation of epithelial cells |
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activating keratinocyte migration and stimulating wound healing |
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inhibitor of phosphate transport |
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promoting the proliferation of embryonic pancreatic epithelial cells |
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specific mitogen for epithelial cells, is implicated in epithelial tissue repair and cancer |
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playing a role in maintaining gastric mucosa integrity |
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perichondrial FGF1, FGF2, FGF6, FGF7, FGF9, FGF18, FGF21, FGF22 regulate growth plate chondrogenesis |
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regulate keratinocyte proliferation and differentiation by binding to the tyrosine kinase KGF receptor (FGFR2) |
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may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG signaling pathway |
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important effector of epithelial growth and tissue homeostasis in various organs including the pancreas |
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functional niche signal for the stimulation of liver progenitor cells |
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promotes beta-cell regeneration by stimulating duct cell proliferation |
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paracrine factor that regulate the proliferation, migration and differentiation of the limbal epithelial cells by upregulation of TP63 through the MAPK14 pathway |
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paracrine growth factor for tissue growth and regeneration |
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promotes preadipocyte proliferation by an autocrine mechanism that involves activation of the PI3K/Akt signaling pathway |
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FGF22 and FGF7, promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers |
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FGF22, FGF7 act as target-derived presynaptic organizers and help to organize specific presynaptic terminals in the mammalian brain |
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is a novel regulator of CYP7A1 expression in hepatocytes and may prevent hepatocytes from accumulating toxic bile acids during liver injury and fibrosis |
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acts as a key paracrine mediator for proliferation, migration, differentiation of epithelial cells |
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FGF7 and FGF10 are involved in the proliferation of ameloblastoma cells through the MAPK pathway |
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stimulates osteogenic differentiation, but not proliferation, in ESCs, by activating ERK/RUNX2 signaling |
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acts indirectly by stimulating stromal cells in an autocrine manner |
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important player in epithelial cell protection and differentiation |
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role of FGF7 in the regulation of sequential steps of the autophagic process and strengthen the hypothesis of a direct interplay between autophagy and differentiation |
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key roles played, on the melanosome transfer in normal skin, by FGF7 released by dermal fibroblasts and by its receptor FGFR2 expressed and activated on the epidermal keratinocytes |
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FGF22 and FGF7 are postsynaptic-cell-derived presynaptic organizers necessary for excitatory and inhibitory presynaptic differentiation, respectively, in the hippocampus |