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FLASH GENE
Symbol FGF7 contributors: mct - updated : 24-02-2015
HGNC name fibroblast growth factor 70
HGNC id 3685
Location 15q21.2      Physical location : 49.715.374 - 49.779.522
Synonym name
  • palifermin
  • keratinocyte growth factor
  • fibroblast growth factor 7 (keratinocyte growth factor)
  • Synonym symbol(s) KGF, HBGF7
    DNA
    TYPE virus associated
    STRUCTURE 64.15 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    SEMA6D 15q15.2 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D LOC283652 MYEF2 15q15.1 myelin expression factor 2 SLC12A1 15q15-q21 solute carrier family 12 (sodium/potassium/chloride transporters), member 1 DUT 15q21.1 dUTP pyrophosphatase FBN1 15q21.1 fibrillin 1 (Marfan syndrome) LOC388119 15 similar to Oxr1 protein KIAA0912 15q15.3 KIAA0912 protein CRI1 15q21.1-q21.2 CREBBP/EP300 inhibitory protein 1 LOC390582 15 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 KIAA0256 15q15.3 KIAA0256 gene product TRIP15 15q21.2 KIAA0256 gene product LOC390583 15 similar to Protein C6orf66 (HSPC125) (My013 protein) GALK2 15q21.1 galactokinase 2 FLJ32800 15q15.3 hypothetical protein FLJ32800 LOC390584 15 similar to putative intramembrane cleaving protease; presenilin-like protein 2; intramembrane protease 3 FGF7 15q15-q21.1 fibroblast growth factor 7 (keratinocyte growth factor) MDS009 15q15.3 x 009 protein LOC388120 15 hypothetical gene supported by BC013357; NM_016120 ATP8B4 15q15.3 ATPase, Class I, type 8B, member 4 SLC27A2 15q21.2 solute carrier family 27 (fatty acid transporter), member 2 HDC 15q15-q21 histidine decarboxylase GABPB2 15q15.2 GA binding protein transcription factor, beta subunit 2, 47kDa FLJ10038 15q15.3 hypothetical protein FLJ10038 USP8 6p21.3 ubiquitin specific protease 8 TRPM7 15q21 transient receptor potential cation channel, subfamily M, member 7 SPPL2A 15q15.3 putative intramembrane cleaving protease AP4E1 15q15.2 adaptor-related protein complex 4, epsilon 1 subunit LOC388121 15 similar to TNF-induced protein CYP19A1 15q21.1 cytochrome P450, family 19, subfamily A, polypeptide 1 FLJ11181 15q15.3 hypothetical protein FLJ11181 CRG-L2 15q15.3 likely ortholog of mouse cancer related gene - liver 2 RC3 15q15.3 rabconnectin-3 SCG3 15q21 secretogranin III MGC35274 15q21.1 hypothetical protein MGC35274 TMOD2 15q21.1-q21.2 tropomodulin 2 (neuronal) TMOD3 15q21.1-q21.2 tropomodulin 3 (ubiquitous) LOC123169 15q21.1 senescence downregulated leo1-like MAPK6 15q21 mitogen-activated protein kinase 6 BCL2L10 15q21 BCL2-like 10 (apoptosis facilitator) GNB5 15q21 guanine nucleotide binding protein (G protein), beta 5 MYO5C 15q21 myosin VC MYO5A 15q21.1 myosin VA (heavy polypeptide 12, myoxin) EEF1B1 15q15.1-q15.3 eukaryotic translation elongation factor 1 beta 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3936 22.5 194 - 1995 7744756
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    Hearing/Equilibriumearinnercochlea highly
    Nervousbrainlimbic systemhippocampus highly Homo sapiens
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningcorneal epithelium  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    Lymphoid/Immunestellate Homo sapiens
    Nervouspyramidal cell Homo sapiens
    reproductivemammary gland
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text embryonic pancreatic mesenchyme
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • a FGF domain
  • HOMOLOGY
    interspecies ortholog to murine Fgf7
    Homologene
    FAMILY
  • heparin-binding growth factors family
  • FGF7 subfamily
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • regulation of proliferation and differentiation of epithelial cells
  • activating keratinocyte migration and stimulating wound healing
  • inhibitor of phosphate transport
  • promoting the proliferation of embryonic pancreatic epithelial cells
  • specific mitogen for epithelial cells, is implicated in epithelial tissue repair and cancer
  • playing a role in maintaining gastric mucosa integrity
  • perichondrial FGF1, FGF2, FGF6, FGF7, FGF9, FGF18, FGF21, FGF22 regulate growth plate chondrogenesis
  • regulate keratinocyte proliferation and differentiation by binding to the tyrosine kinase KGF receptor (FGFR2)
  • may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG signaling pathway
  • important effector of epithelial growth and tissue homeostasis in various organs including the pancreas
  • functional niche signal for the stimulation of liver progenitor cells
  • promotes beta-cell regeneration by stimulating duct cell proliferation
  • paracrine factor that regulate the proliferation, migration and differentiation of the limbal epithelial cells by upregulation of TP63 through the MAPK14 pathway
  • paracrine growth factor for tissue growth and regeneration
  • promotes preadipocyte proliferation by an autocrine mechanism that involves activation of the PI3K/Akt signaling pathway
  • FGF22 and FGF7, promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers
  • FGF22, FGF7 act as target-derived presynaptic organizers and help to organize specific presynaptic terminals in the mammalian brain
  • is a novel regulator of CYP7A1 expression in hepatocytes and may prevent hepatocytes from accumulating toxic bile acids during liver injury and fibrosis
  • acts as a key paracrine mediator for proliferation, migration, differentiation of epithelial cells
  • FGF7 and FGF10 are involved in the proliferation of ameloblastoma cells through the MAPK pathway
  • stimulates osteogenic differentiation, but not proliferation, in ESCs, by activating ERK/RUNX2 signaling
  • acts indirectly by stimulating stromal cells in an autocrine manner
  • important player in epithelial cell protection and differentiation
  • role of FGF7 in the regulation of sequential steps of the autophagic process and strengthen the hypothesis of a direct interplay between autophagy and differentiation
  • key roles played, on the melanosome transfer in normal skin, by FGF7 released by dermal fibroblasts and by its receptor FGFR2 expressed and activated on the epidermal keratinocytes
  • FGF22 and FGF7 are postsynaptic-cell-derived presynaptic organizers necessary for excitatory and inhibitory presynaptic differentiation, respectively, in the hippocampus
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text lung development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    protein
  • ligand for FGFR2 (KGFR)
  • targeting HAS2 and HAS3 in keratinocytes (stimulating migration and hyaluronan synthesis in the epidermis by activation of keratinocyte HAS2 and HAS3)
  • interacting with cortactin (involved in keratinocyte migration promoted by both FGF7 and FGF10)
  • BDKRB2, FGF7 and HIST2H2BE are direct IRX1 targets
  • FGF7 inhibited CYP7A1 gene expression in hepatocytes, and suppression of CYP7A1 expression by FGF7 was mediated by FGFR2 and its downstream JNK signaling cascade
  • IL19 is important for cutaneous wound healing because it upregulates FGF7 expression
  • produced by mesenchymal cells, and binds to and activates the specific receptor tyrosine kinase FGFR2 isoform IIIb, which in turn rapidly activates RAS-mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase-AKT signaling pathways
  • FGF7 and its cognate receptor FGFR2IIIb are specifically expressed in mesenchymal stromal cells, and FGF7 supports hematopoietic stem and progenitor cells (HSPCs) maintenance
  • cell & other
    REGULATION
    Other regulated mainly by posttranscriptional mechanisms
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oncogenic osteomalacia
    tumoral     --over  
    in the mucosal epithelium of all gastric inflammation cases and also in gastric adenocarcinoma
    Susceptibility to chronic obstructive pulmonary disease (COPD)
    Variant & Polymorphism SNP
  • SNPs (rs12591300 and rs4480740) were significantly associated with COPD
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    attractive target for gastric cancer prevention and treatment
    digestiveliver 
    potential therapeutic target for liver diseases
    ANIMAL & CELL MODELS
  • Fgf7-deficient mice exhibited markedly depressed liver progenitor cells (LPCs) expansion and higher mortality upon toxin-induced hepatic injury