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FLASH GENE
Symbol FGF7 contributors: mct - updated : 24-02-2015
HGNC name fibroblast growth factor 70
HGNC id 3685
Location 15q21.2      Physical location : 49.715.374 - 49.779.522
Synonym name
  • palifermin
  • keratinocyte growth factor
  • fibroblast growth factor 7 (keratinocyte growth factor)
  • Synonym symbol(s) KGF, HBGF7
    DNA
    TYPE virus associated
    STRUCTURE 64.15 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3936 22.5 194 - 1995 7744756
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    Hearing/Equilibriumearinnercochlea highly
    Nervousbrainlimbic systemhippocampus highly Homo sapiens
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningcorneal epithelium  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    Lymphoid/Immunestellate Homo sapiens
    Nervouspyramidal cell Homo sapiens
    reproductivemammary gland
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text embryonic pancreatic mesenchyme
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • a FGF domain
  • HOMOLOGY
    interspecies ortholog to murine Fgf7
    Homologene
    FAMILY
  • heparin-binding growth factors family
  • FGF7 subfamily
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • regulation of proliferation and differentiation of epithelial cells
  • activating keratinocyte migration and stimulating wound healing
  • inhibitor of phosphate transport
  • promoting the proliferation of embryonic pancreatic epithelial cells
  • specific mitogen for epithelial cells, is implicated in epithelial tissue repair and cancer
  • playing a role in maintaining gastric mucosa integrity
  • perichondrial FGF1, FGF2, FGF6, FGF7, FGF9, FGF18, FGF21, FGF22 regulate growth plate chondrogenesis
  • regulate keratinocyte proliferation and differentiation by binding to the tyrosine kinase KGF receptor (FGFR2)
  • may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG signaling pathway
  • important effector of epithelial growth and tissue homeostasis in various organs including the pancreas
  • functional niche signal for the stimulation of liver progenitor cells
  • promotes beta-cell regeneration by stimulating duct cell proliferation
  • paracrine factor that regulate the proliferation, migration and differentiation of the limbal epithelial cells by upregulation of TP63 through the MAPK14 pathway
  • paracrine growth factor for tissue growth and regeneration
  • promotes preadipocyte proliferation by an autocrine mechanism that involves activation of the PI3K/Akt signaling pathway
  • FGF22 and FGF7, promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers
  • FGF22, FGF7 act as target-derived presynaptic organizers and help to organize specific presynaptic terminals in the mammalian brain
  • is a novel regulator of CYP7A1 expression in hepatocytes and may prevent hepatocytes from accumulating toxic bile acids during liver injury and fibrosis
  • acts as a key paracrine mediator for proliferation, migration, differentiation of epithelial cells
  • FGF7 and FGF10 are involved in the proliferation of ameloblastoma cells through the MAPK pathway
  • stimulates osteogenic differentiation, but not proliferation, in ESCs, by activating ERK/RUNX2 signaling
  • acts indirectly by stimulating stromal cells in an autocrine manner
  • important player in epithelial cell protection and differentiation
  • role of FGF7 in the regulation of sequential steps of the autophagic process and strengthen the hypothesis of a direct interplay between autophagy and differentiation
  • key roles played, on the melanosome transfer in normal skin, by FGF7 released by dermal fibroblasts and by its receptor FGFR2 expressed and activated on the epidermal keratinocytes
  • FGF22 and FGF7 are postsynaptic-cell-derived presynaptic organizers necessary for excitatory and inhibitory presynaptic differentiation, respectively, in the hippocampus
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text lung development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    protein
  • ligand for FGFR2 (KGFR)
  • targeting HAS2 and HAS3 in keratinocytes (stimulating migration and hyaluronan synthesis in the epidermis by activation of keratinocyte HAS2 and HAS3)
  • interacting with cortactin (involved in keratinocyte migration promoted by both FGF7 and FGF10)
  • BDKRB2, FGF7 and HIST2H2BE are direct IRX1 targets
  • FGF7 inhibited CYP7A1 gene expression in hepatocytes, and suppression of CYP7A1 expression by FGF7 was mediated by FGFR2 and its downstream JNK signaling cascade
  • IL19 is important for cutaneous wound healing because it upregulates FGF7 expression
  • produced by mesenchymal cells, and binds to and activates the specific receptor tyrosine kinase FGFR2 isoform IIIb, which in turn rapidly activates RAS-mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase-AKT signaling pathways
  • FGF7 and its cognate receptor FGFR2IIIb are specifically expressed in mesenchymal stromal cells, and FGF7 supports hematopoietic stem and progenitor cells (HSPCs) maintenance
  • cell & other
    REGULATION
    Other regulated mainly by posttranscriptional mechanisms
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oncogenic osteomalacia
    tumoral     --over  
    in the mucosal epithelium of all gastric inflammation cases and also in gastric adenocarcinoma
    Susceptibility to chronic obstructive pulmonary disease (COPD)
    Variant & Polymorphism SNP
  • SNPs (rs12591300 and rs4480740) were significantly associated with COPD
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    attractive target for gastric cancer prevention and treatment
    digestiveliver 
    potential therapeutic target for liver diseases
    ANIMAL & CELL MODELS
  • Fgf7-deficient mice exhibited markedly depressed liver progenitor cells (LPCs) expansion and higher mortality upon toxin-induced hepatic injury