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FLASH GENE

Symbol

FGF6

contributors: mct - updated : 25-02-2015

HGNC name	fibroblast growth factor 6
HGNC id	3684

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p13.32      Physical location : 4.543.307 - 4.554.780
Synonym name	heparin secretory-transforming protein 2
Synonym symbol(s)	HSTF2, HBGF-6, HST2

DNA

TYPE	functioning gene
STRUCTURE	11.47 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map	pter - D12S1050 - D12S879 - D12S188 - (D12S1543 ,D12S1685 ,D12S983 ) - D12S1880 - CCND2 - D12S1530 - FGF6 - D12S1624 - (D12S314 ,D12S1179E - (KCNA1 ,D12S1879 ) - D12S1263 - D12S1531 - D12S1542 - D12S1594 - KCNA5 - (D12S93 ,D12S328 ,D12S804 ) - D12S878 - cen
Authors	4st Workshop chrom.12 (97)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020996 3 - 747 NP_066276 - 208 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text	pregnancy, embryo, during embryonic development

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

homolog to HST oncogene

Homologene

FAMILY	heparin-binding growth factors family
	FGF4 subfamily

CATEGORY

protooncogene , signaling growth factor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	may be playing a role in muscle regeneration or differentiation
	has likely a dual function in muscle regeneration, stimulating myoblast proliferation/migration and muscle differentiation/hypertrophy in a dose-dependent manner
	perichondrial FGF1, FGF2, FGF6, FGF7, FGF9, FGF18, FGF21, fGF22 regulate growth plate chondrogenesis
	may be considered a regulator of bone metabolism as shown by its activity on both osteoblasts and osteoclasts
	crucial and unexpected role for FGF6 in muscle integrity and muscle protection against mechanical stress

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

TGFB1-SMAD4-FGF6 signaling cascade plays a crucial role in myogenic cell fate determination and lineage progression during tongue myogenesis

a component

INTERACTION

DNA

RNA

small molecule

protein	specific relationship between FGF6 and SPRY2, both being known for their particular involvement in myogenesis
	key ligand for fibroblast growth factor receptor 4 (FGFR4) during muscle regeneration

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostatic intraepithelial neoplasia and prostate cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS