basic FUNCTION
| physiological regulator of phosphate homeostasis |
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acting as a hormone and regulating kidney functions |
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key humoral factor in phosphate homeostasis and skeletogenesis |
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hormone that regulates serum phosphate level in contrast to other FGF family members that work as local factors |
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hormone-like factor that is thought to play an important role in phosphate homeostasis |
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hormone that regulates serum phosphate and 1,25-dihydroxyvitamin D levels |
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hormone regulating phosphate and calcitriol metabolism, that has unveiled the mechanisms that coordinate these renal proximal tubule functions |
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reduces renal absorption of phosphate by downregulating the sodium-phosphate cotransporter SLC34A1 |
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regulates phosphate homeostasis in kidney |
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FGF19 and FGF21 can regulate glucose, lipid, and energy metabolism, while FGF23 regulates phosphate homeostasis |
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acts on kidney to inhibit phosphate reabsorption and vitamin D synthesis |
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bone-derived endocrine regulator of phosphate homeostasis which inhibits renal tubular phosphate reabsorption |
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play crucial roles in the regulation of phosphate homeostasis |
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hormone released primarily by osteocytes that regulates phosphate and vitamin D metabolism |
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bone/heart endocrine factor and may be an important mediator of cardiac Ca(2+) regulation and contractile function during chronic kidney disease |
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WNT-independent function of FGF23 in the regulation of phosphate homeostasis |
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FGF23, not KL, is a calcium-conserving hormone in the kidney |
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bone-derived hormone protecting against the potentially deleterious effects of hyperphosphatemia by suppression of phosphate reabsorption and of active vitamin D hormone synthesis in the kidney |
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acts independently on proximal and distal tubular epithelium |
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role of FGF23/FGFR4 signaling in the regulation of cardiac remodeling and function |
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FGF19, FGF21 and FGF23 are circulating hormones that regulate critical metabolic processes in a variety of tissues |